Evidence map›Paper›PMID 29985127›Full record

ArticleeLife2018

Removing physiological motion from intravital and clinical functional imaging data.

Sean C Warren, Max Nobis, Astrid Magenau, Yousuf H Mohammed, David Herrmann, Imogen Moran, Claire Vennin, James Rw Conway, Pauline Mélénec, Thomas R Cox and 8 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
7.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
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  7. Review
  8. Multiphoton intravital microscopy of rodents.Nature reviews. Methods primers · 2022
    Article
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  13. Cancer Cell Invasion and Metastasis in Zebrafish Models (Danio rerio).Methods in molecular biology (Clifton, N.J.) · 2021
    Article
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  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 3 countries.

Sean C WarrenKinghorn Cancer Centre, Garvan Institute of Medical Research, University of New South Wales, Sydney, Australia.ORCID 0000-0002-5253-7147
Max NobisKinghorn Cancer Centre, Garvan Institute of Medical Research, University of New South Wales, Sydney, Australia.ORCID 0000-0002-1861-1390
Astrid MagenauKinghorn Cancer Centre, Garvan Institute of Medical Research, University of New South Wales, Sydney, Australia.
Yousuf H MohammedTherapeutics Research Centre, Diamantina Institute, Faculty of Medicine, University of Queensland, Woolloongabba, Australia.
David HerrmannKinghorn Cancer Centre, Garvan Institute of Medical Research, University of New South Wales, Sydney, Australia.ORCID 0000-0002-9514-7501
Imogen MoranSt Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia.
Claire VenninKinghorn Cancer Centre, Garvan Institute of Medical Research, University of New South Wales, Sydney, Australia.
James Rw ConwayKinghorn Cancer Centre, Garvan Institute of Medical Research, University of New South Wales, Sydney, Australia.
Pauline MélénecKinghorn Cancer Centre, Garvan Institute of Medical Research, University of New South Wales, Sydney, Australia.
Thomas R CoxKinghorn Cancer Centre, Garvan Institute of Medical Research, University of New South Wales, Sydney, Australia.ORCID 0000-0001-9294-1745
Yingxiao WangDepartment of Bioengineering, Institute of Engineering in Medicine, University of California, San Diego, San Diego, United States.ORCID 0000-0003-0265-326X
Jennifer P MortonCancer Research UK Beatson Institute, Glasgow, United Kingdom.
Heidi Ce WelchSignalling Programme, Babraham Institute, Cambridge, United Kingdom.
Douglas StrathdeeCancer Research UK Beatson Institute, Glasgow, United Kingdom.ORCID 0000-0003-2959-4327
Kurt I AndersonCancer Research UK Beatson Institute, Glasgow, United Kingdom.ORCID 0000-0002-9324-9598
Tri Giang PhanSt Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia.ORCID 0000-0002-4909-2984
Michael S RobertsTherapeutics Research Centre, Diamantina Institute, Faculty of Medicine, University of Queensland, Woolloongabba, Australia.
Paul TimpsonKinghorn Cancer Centre, Garvan Institute of Medical Research, University of New South Wales, Sydney, Australia.
Garvan Institute of Medical Research · AUCancer Research UK Scotland Institute · GBThe University of Queensland · AUBabraham Institute · GBThe Francis Crick Institute · GBUniversity of California San Diego · US

Funding

Integrative Bioengineering of Heart, Vessels, and BloodT32HL105373 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHIEN, SHU, INTAGLIETTA, MARCOS · 2010 to 2019
$3.6M
Locus-specific Imaging of Dynamic Histone Methylations during ReprogrammingR01GM125379 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHIEN, SHU, WANG, YINGXIAO · 2017 to 2020
$2.4M
Biotechnology and Biological Sciences Research Council BBS/E/B/000C0411Biotechnology and Biological Sciences Research Council Institute Strategic Programme Grant BB/P013384/1Cancer Research UK 15565NIGMS NIH HHS R01 GM125379
6 · The paper itself

Abstract

Intravital microscopy can provide unique insights into the function of biological processes in a native context. However, physiological motion caused by peristalsis, respiration and the heartbeat can present a significant challenge, particularly for functional readouts such as fluorescence lifetime imaging (FLIM), which require longer acquisition times to obtain a quantitative readout. Here, we present and benchmark

Indexed as

Imaging, Three-DimensionalIntravital MicroscopyMotionAlgorithmsAnimalsBiosensing TechniquesCell AdhesionComputer SimulationFluorescence Resonance Energy TransferGuanosine TriphosphateHumansIntestinesMiceMicroscopy, FluorescenceModels, BiologicalNeoplasm MetastasisGuanosine TriphosphateNeuropeptidesrac1 GTP-Binding ProteinRac1 protein, mousesrc-Family Kinasescell biologycomputational biologyFLIMFREThumanintravital microscopymotion correctionmousemultiphotonsystems biology

Identifiers

PMID29985127
PMCPMC6037484
OpenAlexW2882115054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.