ArticleNeuropsychology2018
Occupational cognitive complexity in earlier adulthood is associated with brain structure and cognitive health in midlife: The CARDIA study.
Article in Neuropsychology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- ChatGPT-estimated occupational complexity predicts cognitive outcomes and cortical thickness above and beyond socioeconomic status among older adults.GeroScience · 2025Article
- Cognitive Health Disparities by Race and Ethnicity: The Role of Occupational Complexity and Occupational Status.Work, aging and retirement · 2025Article
- Frontotemporal structure preservation underlies the protective effect of lifetime intellectual cognitive reserve on cognition in the elderly.Alzheimer's research & therapy · 2024Article
- Systematic examination of methodological inconsistency in operationalizing cognitive reserve and its impact on identifying predictors of late-life cognition.BMC geriatrics · 2023Review
- Actigraphy-estimated physical activity is associated with functional and structural brain connectivity among older adults.Neurobiology of aging · 2022Article
- Age-Dependent Association Between Cognitive Reserve Proxy and Longitudinal White Matter Microstructure in Older Adults.Frontiers in psychology · 2022Article
- Quantitative MRI Evidence for Cognitive Reserve in Healthy Elders and Prodromal Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2022Article
- Higher literacy is associated with better white matter integrity and cognition in middle age.Alzheimer's & dementia (Amsterdam, Netherlands) · 2022Article
- Midlife occupational cognitive requirements protect cognitive function in old age by increasing cognitive reserve.Frontiers in psychology · 2022Article
- Brain Reserve in a Case of Cognitive Resilience to Severe Leukoaraiosis.Journal of the International Neuropsychological Society : JINS · 2021Article
- Do High Mental Demands at Work Protect Cognitive Health in Old AgeFrontiers in aging neuroscience · 2020Article
- Occupational Physical Stress Is Negatively Associated With Hippocampal Volume and Memory in Older Adults.Frontiers in human neuroscience · 2020Article
- High occurrence of transportation and logistics occupations among vascular dementia patients: an observational study.Alzheimer's research & therapy · 2019Observational
- Lifespan Intellectual Factors, Genetic Susceptibility, and Cognitive Phenotypes in Aging: Implications for Interventions.Frontiers in aging neuroscience · 2019Review
- Occupational Patterns of Structural Brain Health: Independent Contributions Beyond Education, Gender, Intelligence, and Age.Frontiers in human neuroscience · 2019Article
- Understanding Structure and Function as a Model for 21st-Century Health Care.Integrative medicine (Encinitas, Calif.) · 2018Article
- Cognitive Decline on the Bench: A Text Analysis of the Opinions of Justice Stephen Field.Behavioral sciences & the lawArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveIn line with cognitive reserve theory, higher occupational cognitive complexity is associated with reduced cognitive decline in older adulthood. How and when occupational cognitive complexity first exerts protective effects during the life span remains unclear. We investigated associations between occupational cognitive complexity during early to midadulthood and brain structure and cognition in midlife.
methodParticipants were 669 adults from the Coronary Artery Risk Development in Young Adults study (aged 18-30 years at baseline, 52% female, 38% Black). We calculated scores reflecting occupational cognitive complexity using Census Occupation Codes (years 10 and 15) and Occupational Information Network (O*NET) data. At year 25, participants had structural brain magnetic resonance imaging, diffusion tensor imaging, and cognitive testing (Rey Auditory Verbal Learning Test, Digit Symbol Substitution Test, Stroop). In adjusted mixed models, we examined associations between occupational cognitive complexity during early to midadulthood and midlife brain structure, specifically gray matter volume and white matter fractional anisotropy, and cognition in midlife (all outcomes converted to z-scores).
resultsHigher occupational cognitive complexity was associated with greater white matter fractional anisotropy (estimate = 0.10,
conclusionsOccupational cognitive complexity earlier in adulthood is associated with better white matter integrity, processing speed, and executive function in midlife. These associations may capture how occupational cognitive complexity contributes to cognitive reserve. (PsycINFO Database Record (c) 2018 APA, all rights reserved).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.