Evidence map›Paper›PMID 29984992›Full record

ArticleAnalytical chemistry2018

Differentiating Isomeric Deprotonated Glucuronide Drug Metabolites via Ion/Molecule Reactions in Tandem Mass Spectrometry.

John Y Kong, Zaikuan Yu, Mckay W Easton, Edouard Niyonsaba, Xin Ma, Ravikiran Yerabolu, Huaming Sheng, Tiffany M Jarrell, Zhoupeng Zhang, Arun K Ghosh and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

John Y KongDepartment of Chemistry , Purdue University , West Lafayette , Indiana 47907 , United States.
Zaikuan YuDepartment of Chemistry , Purdue University , West Lafayette , Indiana 47907 , United States.
Mckay W EastonDepartment of Chemistry , Purdue University , West Lafayette , Indiana 47907 , United States.
Edouard NiyonsabaDepartment of Chemistry , Purdue University , West Lafayette , Indiana 47907 , United States.
Xin MaDepartment of Chemistry , Purdue University , West Lafayette , Indiana 47907 , United States.ORCID 0000-0002-7058-0165
Ravikiran YeraboluDepartment of Chemistry , Purdue University , West Lafayette , Indiana 47907 , United States.
Huaming ShengDepartment of Analytical Research & Development , Merck & Co., Inc. , Rahway , New Jersey 07065 , United States.
Tiffany M JarrellDepartment of Animal Health , Merck Animal Health , Rahway , New Jersey 07065 , United States.
Zhoupeng ZhangDepartment of Pharmacokinetics, Pharmacodynamics, & Drug Metabolism , Merck & Co., Inc. , West Point , Pennsylvania 19486 , United States.
Arun K GhoshDepartment of Chemistry , Purdue University , West Lafayette , Indiana 47907 , United States.ORCID 0000-0003-2472-1841
Hilkka I KenttämaaDepartment of Chemistry , Purdue University , West Lafayette , Indiana 47907 , United States.ORCID 0000-0001-8988-6984
Purdue University West Lafayette · USMerck & Co., Inc., Rahway, NJ, USA (United States) · US

Funding

Design & Synthesis of Nonpeptide Protease InhibitorsR37GM053386 · NIGMS · PURDUE UNIVERSITY · PI GHOSH, ARUN K · 2011 to 2018
$3.9M
DESIGN AND SYNTHESIS OF NONPEPTIDE PROTEASE INHIBITORSR01GM053386 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GHOSH, ARUN K · 1995 to 2010
$3.7M
NIGMS NIH HHS R01 GM053386NIGMS NIH HHS R37 GM053386
6 · The paper itself

Abstract

Isomeric O- and N-glucuronides are common drug metabolites produced in phase II of drug metabolism. Distinguishing these isomers by using common analytical techniques has proven challenging. A tandem mass spectrometric method based on gas-phase ion/molecule reactions of deprotonated glucuronide drug metabolites with trichlorosilane (HSiCl

Indexed as

Chromatography, High Pressure LiquidGlucuronidesIsomerismPharmaceutical PreparationsProtonsSilanesTandem Mass SpectrometryGlucuronidesPharmaceutical PreparationsProtonsSilanestrichlorosilane

Identifiers

PMID29984992
PMCPMC6686676
OpenAlexW2824542195

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.