Evidence map›Paper›PMID 29984915›Full record

ArticleJournal of applied clinical medical physics2018

Feasibility of optimizing intensity-modulated radiation therapy plans based on measured mucosal dose adjacent to dental fillings and toxicity outcomes.

Seung Won Seol, Sonya Aggarwal, Rie von Eyben, Ziwei Wang, Cato Chan, Carmen Say, Lei Xing, Wendy Hara, Yong Yang, Quynh Thu Le

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied clinical medical physics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Seung Won SeolDepartment of Internal Medicine, Icahn School of Medicine at Mount Sinai (VA), Bronx, NY, USA.
Sonya AggarwalDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA.
Rie von EybenDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA.
Ziwei WangSan Diego School of Medicine, University of California, San Diego, CA, USA.
Cato ChanKeck School of Medicine of USC, Los Angeles, CA, USA.
Carmen SayDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA.
Lei XingDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA.
Wendy HaraDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA.
Yong YangDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA.
Quynh Thu LeDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA.
Stanford University · USIcahn School of Medicine at Mount Sinai · USKeck Hospital of USC · USUniversity of California, San Diego · US

Funding

Varian Medical System
6 · The paper itself

Abstract

We prospectively investigated the feasibility of IMRT treatment plan optimization based on dosimeter measurements of lateral tongue mucosal dose adjacent to the dental fillings and evaluated dose-toxicity relationship and factors affecting oral mucositis (OM) in head and neck cancer patients. Twenty-nine head and neck cancer patients with metallic dental fillings who were scheduled to undergo fractionated external beam radiation therapy (RT) ± chemotherapy were enrolled. The lateral tongue dose was measured and if the calculated dose for the entire treatment was ≥35 Gy, a re-plan was generated to reduce the lateral tongue mucosal dose. OM was graded weekly according to Common Terminology Criteria for Adverse Events version 4.0 and the patients completed the Oral Mucositis Weekly Questionnaire-Head and Neck Cancer. The result showed that it was not feasible to optimize the IMRT plan based on measured tongue dose in most of the patients who needed re-plan as re-planning compromised the target coverage in 60% of these patients. The duration of grade (Gr) 2 OM was correlated with measured lateral tongue dose (P = 0.050). Concurrent cetuximab was significantly associated with faster onset of Gr2 OM than concurrent cisplatin (P = 0.006) and with longer duration of OM (P = 0.041) compared to concurrent cisplatin or IMRT-alone. The pattern of reported pain over time was significantly different for each treatment type (RT and cetuximab, RT and cisplatin and RT-alone) and depending on the dose level (P = 0.006). In conclusion, optimizing the IMRT plan based on measured lateral tongue dose was not feasible. Measured lateral tongue dose was significantly correlated with longer duration of OM ≥Gr2, and concurrent cetuximab was associated with earlier onset and longer duration of OM ≥Gr2.

Indexed as

Radiotherapy, Intensity-ModulatedAdultAgedAged, 80 and overCetuximabCisplatinFemaleHead and Neck NeoplasmsHumansMaleMiddle AgedMouth MucosaProspective StudiesRadiation DosageCetuximabCisplatindental fillinghead and neck cancerIMRToral mucositis

Identifiers

PMID29984915
PMCPMC6123139
OpenAlexW2853348511

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.