Evidence map›Paper›PMID 29984912›Full record

ReviewESC heart failure2018

Rationale and design of the randomized multicentre His Optimized Pacing Evaluated for Heart Failure (HOPE-HF) trial.

Daniel Keene, Ahran Arnold, Matthew J Shun-Shin, James P Howard, Sm Afzal Sohaib, Philip Moore, Mark Tanner, Norman Quereshi, Amal Muthumala, Badrinathan Chandresekeran and 10 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in ESC heart failure, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Innovations in Cardiac Implantable Electronic Devices.Cardiovascular drugs and therapy · 2022
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. His-Purkinje Conduction System Pacing: State of the Art in 2020.Arrhythmia & electrophysiology review · 2020
    Review
  12. Review
  13. [Indications for His bundle and left bundle branch pacing].Herzschrittmachertherapie & Elektrophysiologie · 2020
    Review
  14. Article
  15. Observational
  16. Improving Cardiac Resynchronisation Therapy.Arrhythmia & electrophysiology review · 2019
    Review
  17. Review
  18. Device Programming for His Bundle Pacing.Circulation. Arrhythmia and electrophysiology · 2019
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Daniel KeeneImperial College London, London, UK.
Ahran ArnoldImperial College London, London, UK.
Matthew J Shun-ShinImperial College London, London, UK.
James P HowardImperial College London, London, UK.
Sm Afzal SohaibImperial College London, London, UK.
Philip MooreWest Hertfordshire Hospitals NHS Trust, Hertfordshire, UK.
Mark TannerWest Sussex Hospitals NHS Trust, West Sussex, UK.
Norman QuereshiWycombe General Hospital, High Wycombe, UK.
Amal MuthumalaBarts Health NHS Trust, London, UK.
Badrinathan ChandresekeranGreat Western Hospitals NHS Foundation Trust, Swindon, UK.
Paul FoleyGreat Western Hospitals NHS Foundation Trust, Swindon, UK.
Francisco LeyvaUniversity Hospitals Birmingham, Birmingham, UK.
Shaumik AdhyaMedway NHS Foundation Trust, Kent, UK.
Emanuela FalaschettiImperial College Trials Unit, Imperial College London, London, UK.
Hilda TsangImperial College Trials Unit, Imperial College London, London, UK.
Pugal VijayaramanGeisinger Commonwealth School of Medicine, Geisinger Heart Institute, Scranton, PA, USA.
John G F ClelandImperial College London, London, UK.
Berthold StegemannBakken Research Center B.V. Research and Technology, Maastricht, The Netherlands.
Darrel P FrancisImperial College London, London, UK.
Zachary I WhinnettImperial College London, London, UK.

Funding

British Heart Foundation CS/15/3/31405British Heart Foundation FS/10/038British Heart Foundation FS/10/38/28268British Heart Foundation FS/13/44/30291British Heart Foundation FS/14/27/30752British Heart Foundation FS/15/53/31615
6 · The paper itself

Abstract

aimsIn patients with heart failure and a pathologically prolonged PR interval, left ventricular (LV) filling can be improved by shortening atrioventricular delay using His-bundle pacing. His-bundle pacing delivers physiological ventricular activation and has been shown to improve acute haemodynamic function in this group of patients. In the HOPE-HF (His Optimized Pacing Evaluated for Heart Failure) trial, we are investigating whether these acute haemodynamic improvements translate into improvements in exercise capacity and heart failure symptoms. METHODS AND

resultsThis multicentre, double-blind, randomized, crossover study aims to randomize 160 patients with PR prolongation (≥200 ms), LV impairment (EF ≤ 40%), and either narrow QRS (≤140 ms) or right bundle branch block. All patients receive a cardiac device with leads positioned in the right atrium and the His bundle. Eligible patients also receive a defibrillator lead. Those not eligible for implantable cardioverter defibrillator have a backup pacing lead positioned in an LV branch of the coronary sinus. Patients are allocated in random order to 6 months of (i) haemodynamically optimized dual chamber His-bundle pacing and (ii) backup pacing only, using the non-His ventricular lead. The primary endpoint is change in exercise capacity assessed by peak oxygen uptake. Secondary endpoints include change in ejection fraction, quality of life scores, B-type natriuretic peptide, daily patient activity levels, and safety and feasibility assessments of His-bundle pacing.

conclusionsHope-HF aims to determine whether correcting PR prolongation in patients with heart failure and narrow QRS or right bundle branch block using haemodynamically optimized dual chamber His-bundle pacing improves exercise capacity and symptoms. We aim to complete recruitment by the end of 2018 and report in 2020.

Indexed as

Bundle of HisCardiac Pacing, ArtificialHeart FailureHumansMulticenter Studies as TopicRandomized Controlled Trials as TopicAtrioventricular delayHeart failureHis-bundle pacingOptimization

Identifiers

PMID29984912
PMCPMC6165934

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.