Evidence map›Paper›PMID 29984771›Full record

ArticleInternal medicine (Tokyo, Japan)2018

Progressive Encephalomyelitis with Rigidity and Myoclonus Resolving after Thymectomy with Subsequent Anasarca: An Autopsy Case.

Kokoro Ozaki, Takuya Ohkubo, Tetsuo Yamada, Kotaro Yoshioka, Masahiko Ichijo, Takamasa Majima, Shunsuke Kudo, Takumi Akashi, Keiji Honda, Eisaku Ito and 8 more

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Thymoma and Autoimmune Encephalitis: Clinical Manifestations and Antibodies.Neurology(R) neuroimmunology & neuroinflammation · 2021
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Kokoro OzakiDepartment of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan.
Takuya OhkuboDepartment of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan.
Tetsuo YamadaDepartment of Clinical Laboratory Medicine, Graduate School of Health Care Science, Bunkyo Gakuin University, Japan.
Kotaro YoshiokaDepartment of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan.
Masahiko IchijoDepartment of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan.
Takamasa MajimaDepartment of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan.
Shunsuke KudoDepartment of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan.
Takumi AkashiDepartment of Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan.
Keiji HondaDepartment of Otolaryngology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan.
Eisaku ItoDepartment of Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan.
Mayumi WatanabeDepartment of Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan.
Masaki SekineDepartment of Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan.
Miwako HamagakiDepartment of Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan.
Yoshinobu EishiDepartment of Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan.
Nobuo SanjoDepartment of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan.
Satoru IshibashiDepartment of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan.
Hidehiro MizusawaDepartment of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan.
Takanori YokotaDepartment of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan.
Tokyo Medical and Dental University · JPBunkyo Gakuin University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Progressive encephalomyelitis with rigidity and myoclonus (PERM) is an autoimmune disorder involving the brainstem and spinal cord and is sometimes associated with thymoma. We encountered a 75-year-old woman with typical PERM features, glycine receptor antibody, and thymoma. Her neurologic symptoms improved after thymectomy, but she unexpectedly developed anasarca with massive pleural effusions and hypoalbuminemia and finally succumbed to death. The autopsy showed edema and mononuclear infiltration in the pleura but no neuropathological findings typical of PERM. Effective treatment of PERM can reverse the neuropathological signs of encephalomyelitis. The autoimmune nature of anasarca is possible but not proven.

Indexed as

AgedAutoantibodiesAutoimmune DiseasesAutopsyEdemaEncephalomyelitisFatal OutcomeFemaleHumansMuscle RigidityMyoclonusPleural EffusionPostoperative ComplicationsReceptors, GlycineSerum AlbuminThymectomyAutoantibodiesReceptors, GlycineSerum Albuminanasarcaanti-glycine receptor antibodyedemapleural effusionprogressive encephalomyelitis with rigidity and myoclonussystemic fluid retention

Identifiers

PMID29984771
PMCPMC6306531
OpenAlexW2811849602

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.