ArticleJournal of thrombosis and haemostasis : JTH2018
Mechanisms and mitigating factors for venous thromboembolism in chronic kidney disease: the REGARDS study.
Article in Journal of thrombosis and haemostasis : JTH, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Risk factors for venous thromboembolism in patients with chronic kidney disease: a systematic review and meta-analysis.Renal failure · 2024Pooled it
- Causal effect of renal function on venous thromboembolism: a two-sample Mendelian randomization investigation.Journal of thrombosis and thrombolysis · 2022Pooled it
- Association between cardiorespiratory fitness and risk of incident venous thromboembolism: a prospective cohort study.Research and practice in thrombosis and haemostasis · 2026Article
- Increased Risk of Complications and Mortality After Total Joint Arthroplasty in Dialysis-Dependent Patients.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026Article
- Genetic and biological determinants of pulmonary embolism: Insights from Mendelian randomization studies.World journal of experimental medicine · 2026Review
- Scoping review of apixaban and rivaroxaban dosing for atrial fibrillation and venous thromboembolism in advanced chronic kidney disease.International journal of clinical pharmacy · 2026Article
- Causal relationship between chronic kidney disease, renal function, and venous thromboembolism: a bidirectional Mendelian randomization study.Renal failure · 2025Article
- Evaluating preoperative risk factors for deep vein thrombosis in elderly patients with hip fractures and chronic kidney disease: a retrospective study.European journal of medical research · 2025Article
- Proximal ligation of the pulmonary vein stump to prevent postoperative cerebral infarction after a lobectomy†.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2025Article
- Development of a venous thromboembolism risk prediction model for patients with primary membranous nephropathy based on machine learning.Frontiers in pharmacology · 2025Article
- Concerns about the application of resistance exercise with blood-flow restriction and thrombosis risk in hemodialysis patients.Journal of sport and health science · 2024Article
- Endothelial Dysfunction Biomarkers and CKD Incidence in the REGARDS Cohort.Kidney international reports · 2024Article
- Article
- Venous Thromboembolism in Kidney Diseases and Genetic Predisposition.Kidney diseases (Basel, Switzerland) · 2022Review
- Tryptophan Metabolites Regulate Neuropentraxin 1 Expression in Endothelial Cells.International journal of molecular sciences · 2022Article
- Biomarkers as MEDiators of racial disparities in risk factors (BioMedioR): Rationale, study design, and statistical considerations.Annals of epidemiology · 2022Article
- Clinical factors associated with massive pulmonary embolism and PE-related adverse clinical events.International journal of cardiology · 2021Article
- Review
- The diagnostic performance of renal function-adjusted D-dimer testing in individuals suspected of having venous thromboembolism.Haematologica · 2019Observational
- Inhibition of Soluble Epoxide Hydrolase for Renal Health.Frontiers in pharmacology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
Essentials Chronic kidney disease (CKD) is associated with procoagulant and inflammatory biomarkers. We studied the association of CKD and venous thromboembolism (VTE) in a case-cohort study. Factor VIII, D-dimer and C-reactive protein appeared to explain the association of CKD and VTE. Statin use was protective against VTE in those with and without CKD. SUMMARY: Background Chronic kidney disease (CKD) is associated with venous thromboembolism (VTE) risk via unknown mechanisms. Whether factors associated with reduced VTE risk in the general population might also be associated with reduced VTE risk in CKD patients is unknown. Objectives To determine whether thrombosis biomarkers attenuate VTE risk, and whether factors associated with reduced VTE risk are similarly effective in CKD patients. Methods Baseline biomarkers were measured in a cohort (294 VTE cases; 939 non-cases) from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study, a nationwide prospective cohort study of 30 239 persons aged ≥45 years with 4.3 years of follow-up. The hazard ratio (HR) of VTE per 10 mL min
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.