ArticleFish physiology and biochemistry2019
Effects of berberine on growth, liver histology, and expression of lipid-related genes in blunt snout bream (Megalobrama amblycephala) fed high-fat diets.
Article in Fish physiology and biochemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 137 citations in OpenAlex.
- Hepatic stearoyl-CoA desaturase 1 suppresses diet-induced hyperphagia and hepatic lipid accumulation through PPARα activation and ketone body signaling.The Journal of biological chemistry · 2026Article
- Berberine alleviates soybean meal-induced enteritis in hybrid yellow catfish (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Effects of Berberine on Growth Performance, Serum Biochemical Parameters, Hepatic Antioxidant Capacity and Metabolism inLife (Basel, Switzerland) · 2026Article
- Nutritional and physiological effects of high-fat diets in finfish: effects on growth, immunity, lipid metabolism, and intestinal health: a review.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2025Review
- The Potential Role of Intestinal Microbiota on the Intestine-Protective and Lipid-Lowering Effects of Berberine in Zebrafish (Metabolites · 2025Article
- Adipocyte Hyperplasia Facilitated Adipose Tissue Expansion to Alleviate Hepatopancreas Injury in Nile Tilapia (Aquaculture nutrition · 2025Article
- Gut MicrobeAquaculture nutrition · 2025Article
- A Nutritional Bioenergetic Model for Farmed Fish: Effects of Food Composition on Growth, Oxygen Consumption and Waste Production.Aquaculture nutrition · 2025Article
- Effects of glyphosate-based herbicide on target organs of Astyanax altiparanae in different treatments.Journal of molecular histology · 2024Article
- Comparative Transcriptome Analysis Reveals the Impact of a High-Fat Diet on Hepatic Metabolic Function in Tilapia (Animals : an open access journal from MDPI · 2024Article
- Effects of Berberine on Lipid Metabolism, Antioxidant Status, and Immune Response in Liver of Tilapia (Antioxidants (Basel, Switzerland) · 2024Article
- A High-Fat-Diet-Induced Microbiota Imbalance Correlates with Oxidative Stress and the Inflammatory Response in the Gut of Freshwater Drum (Antioxidants (Basel, Switzerland) · 2024Article
- High water temperature raised the requirements of methionine for spotted seabass (Lateolabrax maculatus).Fish physiology and biochemistry · 2024Article
- The Antioxidant and Hepatoprotective Potential of Berberine and Silymarin on Acetaminophen Induced Toxicity inAnimals : an open access journal from MDPI · 2024Article
- Metabolic Research in Aquatic Animal Nutrition, Physiology and Disease.Metabolites · 2023Article
- Effects of dietary berberine on growth performance, lipid metabolism, antioxidant capacity and lipometabolism-related genes expression of AMPK signaling pathway in juvenile black carp (Mylopharyngodon piceus) fed high-fat diets.Fish physiology and biochemistry · 2023Article
- Dietary n-3/n-6 polyunsaturated fatty acid ratio modulates growth performance in spotted seabass (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2023Article
- Peroxisome Proliferator-Activated Receptor Signaling-Mediated 13-S-Hydroxyoctadecenoic Acid Is Involved in Lipid Metabolic Disorder and Oxidative Stress in the Liver of Freshwater Drum,Antioxidants (Basel, Switzerland) · 2023Article
- Effects of Mulberry Leaf Extract on the Liver Function of Juvenile Spotted Sea Bass (Aquaculture nutrition · 2023Article
- Berberine regulates glucose metabolism in largemouth bass by modulating intestinal microbiota.Frontiers in physiology · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Fatty liver of cultured fish often correlates closely with poor growth and low harvest yield. Some Chinese herbs can reduce hepatic fat storage. This study aimed to examine lipid-lowering effect of berberine (BBR) in blunt snout bream (Megalobrama amblycephala). Triplicate groups of fish were fed four experimental diets: low-fat diet (LFD, 5% fat), high-fat diet (HFD, 15% fat), and HFD supplemented with 50 or 100 mg BBR/kg diet (BBR50, BBR100). After 8-week feeding, growth performance, liver histology and fat deposition, and hepatic genes expression were examined. The results showed significant reduction of growth performance and feed intake in fish fed HFD compared to those fed the LFD and BBR50 diets. Supplementing 50 mg BBR/kg to the HFD significantly improved weight gain and feed intake. Higher hepatic fat content and histological abnormalities were found in the liver of fish receiving HFD, and BBR50 and BBR100 could attenuate these abnormalities of liver. Expression of CPT I, AOX, ApoB100, ApoE, and PGC-1α genes was significantly decreased in fish fed HFD, and 50 and 100 mg/kg BBR supplementation could revert the downregulation of these genes. Also, the expression of FATP, LPL, and LDLR genes was upregulated in HFD-fed fish, and their expression was significantly decreased by 50 and 100 mg/kg BBR supplementation. In conclusion, supplementing BBR to HFD could attenuate liver fat deposition and disorders. The fat-lowering effects of BBR appear to be mediated by activating genes related with fatty acid oxidation and decreasing genes for fatty acid uptake.
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