ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2018
Staging of amyloid β, t-tau, regional atrophy rates, and cognitive change in a nondemented cohort: Results of serial mediation analyses.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 27 citations in OpenAlex.
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- Neural basis of motor symptoms in Alzheimer's disease: role of regional tau burden and cognition.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Rethinking neuropsychological test validity in dementia assessment: a critical review in the age of neuroimaging and digital markers.Frontiers in human neuroscience · 2025Review
- Moderating role of triglycerides in the relationship between amyloid-β, hippocampal atrophy, and cognitive decline in mild cognitive impairment and early Alzheimer's disease.Frontiers in aging neuroscience · 2025Article
- Sex differences in the association between repetitive negative thinking and neurofilament light.Npj mental health research · 2024Article
- Predicting the Societal Value of Lecanemab in Early Alzheimer's Disease in Japan: A Patient-Level Simulation.Neurology and therapy · 2023Article
- A Path to Improved Alzheimer's Care: Simulating Long-Term Health Outcomes of Lecanemab in Early Alzheimer's Disease from the CLARITY AD Trial.Neurology and therapy · 2023Article
- Estimated Societal Value of Lecanemab in Patients with Early Alzheimer's Disease Using Simulation Modeling.Neurology and therapy · 2023Article
- Uncovering Diverse Mechanistic Spreading Pathways in Disease Progression of Alzheimer's Disease.Journal of Alzheimer's disease reports · 2023Article
- Partial Least Squares Regression Analysis of Alzheimer's Disease Biomarkers, Modifiable Health Variables, and Cognitive Change in Older Adults with Mild Cognitive Impairment.Journal of Alzheimer's disease : JAD · 2023Article
- A Simulation Model to Evaluate the Potential Impact of Disease-Modifying Treatments on Burden of Illness in Alzheimer's Disease.Neurology and therapy · 2022Article
- The Potential Economic Value of Lecanemab in Patients with Early Alzheimer's Disease Using Simulation Modeling.Neurology and therapy · 2022Article
- Combinatorial model of amyloid β and tau reveals synergy between amyloid deposits and tangle formation.Neuropathology and applied neurobiology · 2022Article
- Low Subicular Volume as an Indicator of Dementia-Risk Susceptibility in Old Age.Frontiers in aging neuroscience · 2022Article
- Associations Between Sub-Threshold Amyloid-β Deposition, Cortical Volume, and Cognitive Function Modulated by APOE ɛ4 Carrier Status in Cognitively Normal Older Adults.Journal of Alzheimer's disease : JAD · 2022Article
- Regional age-related atrophy after screening for preclinical alzheimer disease.Neurobiology of aging · 2022Article
- Presumed small vessel disease, imaging and cognition markers in the Alzheimer's Disease Neuroimaging Initiative.Brain communications · 2021Article
- Association of vascular brain injury, neurodegeneration, amyloid, and cognitive trajectory.Neurology · 2020Article
- Reduced Dynamic Complexity of BOLD Signals Differentiates Mild Cognitive Impairment From Normal Aging.Frontiers in aging neuroscience · 2020Article
- Dynamic association between AT(N) profile and cognition mediated by cortical thickness in Alzheimer's continuum.NeuroImage. Clinical · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
introductionCurrent models posit a sequence of amyloid β (Aβ), tau, atrophy, and cognitive change leading to Alzheimer's disease, but ambiguities remain. We examined these sequences via serial mediations.
methodsWe studied normal controls, early mild cognitive impairment, and late mild cognitive impairment individuals from the Alzheimer's Disease Neuroimaging Initiative 2 database for the mediation of baseline cerebrospinal fluid Aβ effects on 2-year cognitive change via regional longitudinal atrophy rate (AR) alone or AR and tau.
resultsIn normal controls, Aβ correlated directly with regional ARs and memory loss, with no mediations. In early mild cognitive impairment, tau and lateral temporal ARs serially mediated the influence of Aβ on memory while Aβ affected memory via hippocampal AR. Late mild cognitive impairment consistently showed serial mediations of tau followed by atrophy. However, Aβ effects on memory also continued to be specifically mediated by medial temporal ARs without intermediate tau. DISCUSSION: Biomarker sequences vary by region and disease state, suggesting the need to refine current cascade models.
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