ReviewBioMed research international2018
Aging-Induced Biological Changes and Cardiovascular Diseases.
Review in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it, 108 citations in OpenAlex.
- Could Physical Activity Have any Role in Cardiovascular Disease Prevention in Prisoners? A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Heart Rate Variability and Blood Pressure Response to Low-Intensity Endurance Exercise Training Plus Blood Flow Restriction in Individuals with Mild Hypertension: A Randomized Controlled Clinical Trial.Iranian journal of medical sciences · 2025Trial
- Postbiotic metabolites fromExperimental and therapeutic medicine · 2026Article
- Exploring the Therapeutic Effect ofNutrients · 2026Article
- Age and gender effects on echocardiographic and histopathological cardiac phenotypes in healthy adult mice.Animal models and experimental medicine · 2026Article
- Disruption of ATP Synthase Spatiotemporal Organization, CaAging cell · 2026Article
- Diabetes-Related Alterations in Vectorcardiographic Repolarization Geometry: Insights from Physiological and Machine-Learning Analysis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Characterisation of nocturnal arrhythmia avalanche dynamics: Insights from generalised linear model analysis.Journal of sleep research · 2025Article
- A simple blood biomarker based on gene expression describes cardiovascular health-related biological age.GeroScience · 2025Article
- Effects of Long-Term Moderate-Intensity Exercise on Autonomic Nervous System Dysfunction Induced by Cardiac Neurovascular Interface Deterioration.Reviews in cardiovascular medicine · 2025Review
- Tropisetron attenuates D-galactose-induced heart aging in male mice: activation of sirtuin1.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Longevity mechanisms in cardiac aging: exploring calcium dysregulation and senescence.Biogerontology · 2025Review
- Review
- Exceeding the Limits with Nutraceuticals: Looking Towards Parkinson's Disease and Frailty.International journal of molecular sciences · 2024Review
- Review
- Identification of differentially expressed miRNAs involved in vascular aging reveals pathways associated with the endocrine hormone regulation.Biogerontology · 2024Article
- Age-Related Differences in Cardiovascular and Cerebrovascular Responses During the Head-Up Tilt Test: An Exploratory Study Using Continuous Biosignal Data.Sensors (Basel, Switzerland) · 2024Article
- Adverse cardiac events of hypercholesterolemia are enhanced by sitagliptin in sprague dawley rats.Nutrition & metabolism · 2024Article
- The association between dental caries, periodontal diseases, and tooth loss with diabetes mellitus among the elderly population.Journal of diabetes and metabolic disorders · 2024Article
- The Senescent Heart-"Age Doth Wither Its Infinite Variety".International journal of molecular sciences · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging is characterized by functional decline in homeostatic regulation and vital cellular events. This process can be linked with the development of cardiovascular diseases (CVDs). In this review, we discussed aging-induced biological alterations that are associated with CVDs through the following aspects: (i) structural, biochemical, and functional modifications; (ii) autonomic nervous system (ANS) dysregulation; (iii) epigenetic alterations; and (iv) atherosclerosis and stroke development. Aging-mediated structural and biochemical modifications coupled with gradual loss of ANS regulation, vascular stiffening, and deposition of collagen and calcium often disrupt cardiovascular system homeostasis. The structural and biochemical adjustments have been consistently implicated in the progressive increase in mechanical burden and functional breakdown of the heart and vessels. In addition, cardiomyocyte loss in this process often reduces adaptive capacity and cardiovascular function. The accumulation of epigenetic changes also plays important roles in the development of CVDs. In summary, the understanding of the aging-mediated changes remains promising towards effective diagnosis, discovery of new drug targets, and development of new therapies for the treatment of CVDs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.