Evidence map›Paper›PMID 29984207›Full record

ArticleClinical and experimental reproductive medicine2018

Differentiation of human male germ cells from Wharton's jelly-derived mesenchymal stem cells.

Dmab Dissanayake, H Patel, P S Wijesinghe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental reproductive medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Frontiers in cell and developmental biology · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Generation of male germ cellsAsian journal of andrology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Dmab DissanayakeDepartment of Obstetrics and Gynaecology, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
H PatelStemCure Pvt. Ltd., Ahmedabad, India.
P S WijesingheDepartment of Obstetrics and Gynaecology, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveRecapitulation of the spermatogenesis process

methodsHuman WJ-MSCs were propagated by the explant culture method, and cells at the second passage were induced with differentiation medium containing all-

resultsThe gene expression profile was consistent with the stage-specific development of germ cells. The expression of

conclusionHuman WJ-MSCs can be transdifferentiated into more advanced stages of germ cells by a simple two-step induction protocol using retinoic acid and Sertoli cell-conditioned medium.

Indexed as

All-trans retinoic acidGerm cellsMesenchymal stromal cells

Identifiers

PMID29984207
PMCPMC6030615

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.