ReviewClinical and experimental reproductive medicine2018
The effects of oral antioxidants on the semen of men with idiopathic oligoasthenoteratozoospermia.
Review in Clinical and experimental reproductive medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Coenzyme Q10 and Selenium on Seminal Fluid Parameters and Antioxidant Status in Men With Idiopathic Infertility
The Effect of Two Doses of Coenzyme Q10 on Seminal Fluid Parameters and Antioxidant Status: A Randomised Controlled Trial
Effect of Pentoxifylline Plus Coenzyme Q10 Combination Therapy Compared to Coenzyme Q10 Alone on Sperm Motility in Sub-fertile Male With Asthenozoospermia
Who cites it
30 citing papers in PubMed, 65 citations in OpenAlex.
- Hydroxytyrosol protects sperm viability and DNA integrity in human asthenoteratozoospermia during incubation: An experimental study.International journal of reproductive biomedicine · 2026Article
- Avocado (Toxicology research · 2025Article
- The role of oral antioxidants in the improvement of sperm parameters in infertile men.World journal of urology · 2024Review
- The Effect of Selenium Therapy on Semen Parameters, Antioxidant Capacity, and Sperm DNA Fragmentation in Men with Idiopathic Oligoasthenoteratospermia.Biological trace element research · 2023Article
- Obesity-induced oxidative stress and mitochondrial dysfunction negatively affect sperm quality.FEBS open bio · 2023Article
- Role of antioxidants in fertility preservation of sperm - A narrative review.Animal bioscience · 2023Article
- Phytochemical consumption and the risk of teratozoospermia: findings from a hospital-based case-control study in China.Human reproduction open · 2023Article
- Apoptosis, inflammation, and oxidative stress in infertility: A mini review.Toxicology reports · 2023Review
- Coenzyme Q10 improves sperm motility and antioxidant status in infertile men with idiopathic oligoasthenospermia.Clinical and experimental reproductive medicine · 2022Article
- Experimental validation and molecular docking to explore the active components of cannabis in testicular function and sperm quality modulations in rats.BMC complementary medicine and therapies · 2022Article
- Predictors of pregnancy and time to pregnancy in infertile men with idiopathic oligoasthenospermia pre- and post-coenzyme Q10 therapy.Andrologia · 2022Article
- Comparison of the effects of coenzyme Q10 and Centrum multivitamins on semen parameters, oxidative stress markers, and sperm DNA fragmentation in infertile men with idiopathic oligoasthenospermia.Clinical and experimental reproductive medicine · 2022Article
- Antioxidant Paradox in Male Infertility: 'A Blind Eye' on Inflammation.Antioxidants (Basel, Switzerland) · 2022Review
- Ellagic acid improved diabetes mellitus-induced testicular damage and sperm abnormalities by activation of Nrf2.Saudi journal of biological sciences · 2021Article
- Coenzyme Q10, oxidative stress, and male infertility: A review.Clinical and experimental reproductive medicine · 2021Article
- Coenzyme Q10, oxidative stress markers, and sperm DNA damage in men with idiopathic oligoasthenoteratospermia.Clinical and experimental reproductive medicine · 2021Article
- Effect of antioxidant supplementation containing L-carnitine on semen parameters: a prospective interventional study.JBRA assisted reproduction · 2021Article
- Sperm Antioxidant Biomarkers and Their Correlation with Clinical Condition and Lifestyle with Regard to Male Reproductive Potential.Journal of clinical medicine · 2020Article
- Potential Pathogenic Bacteria in Seminal Microbiota of Patients with Different Types of Dysspermatism.Scientific reports · 2020Article
- Oxidative stress and male infertility: current knowledge of pathophysiology and role of antioxidant therapy in disease management.Cellular and molecular life sciences : CMLS · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been estimated that approximately 15% of reproductive-age couples suffer from infertility. Male factors contribute to almost half of infertility cases, and in many patients the underlying cause of oligoasthenoteratozoospermia is unknown. Accumulating evidence suggests that oxidative stress plays a role as a contributing factor to male infertility, and reactive oxygen species have been shown to impair sperm function and motility and to damage sperm membrane and DNA. Therefore, this review explored the evidence provided by studies published from 2002 to 2017 on the impact of oral antioxidants (vitamin C, vitamin E, L-carnitine, coenzyme Q10, zinc, selenium, and pentoxifylline) on seminal fluid parameters in men with idiopathic oligoasthenoteratozoospermia. Most of the studies were randomized controlled studies that investigated the effect of single or combined antioxidants and reported improvements in at least one semen parameter. The most noteworthy effect that was found was that the use of multiple antioxidants increased sperm motility and concentration. Nonetheless, there is a lack of agreement on the dose, the duration of treatment, and whether individual or combined oral antioxidants should be used. Therefore, the current review provides evidence supporting the use of oral antioxidants in the treatment of infertile men with idiopathic oligoasthenoteratozoospermia.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.