ArticleToxicology reports2018
Short term exposure to titanium, aluminum and vanadium (Ti 6Al 4V) alloy powder drastically affects behavior and antioxidant metabolites in vital organs of male albino mice.
Article in Toxicology reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 62 citations in OpenAlex.
- Effect of Rare-Earth Element Microdoping on Ti-6Al-7Nb Alloys for Biomedical Applications: Materials Characterization and In Vivo Biocompatibility Tests.Materials (Basel, Switzerland) · 2026Article
- Surface and in vitro corrosion properties of spark plasma sintered Ti-Zr-Nb-Ta-Ag high entropy alloy for dental implant applications.Scientific reports · 2025Article
- Novel synthesis of AlJournal of materials science. Materials in medicine · 2025Article
- Influence of Deposition Temperature on Microstructure and Properties of Tantalum Oxide Sputtered Coatings.Materials (Basel, Switzerland) · 2025Article
- Developing and analyzing a Nanocomposites coated material for hammertoe implants.Journal of orthopaedics · 2025Article
- Advances in Multifunctional Bioactive Coatings for Metallic Bone Implants.Materials (Basel, Switzerland) · 2022Review
- Article
- Recent Advancements in Materials and Coatings for Biomedical Implants.Gels (Basel, Switzerland) · 2022Review
- Metallic Implants Used in Lumbar Interbody Fusion.Materials (Basel, Switzerland) · 2022Review
- Effect of Surface Tooling Techniques of Medical Titanium Implants on Bacterial Biofilm Formation In Vitro.Materials (Basel, Switzerland) · 2022Article
- Toxicological assessment of nanocrystalline metal alloys with potential applications in the aeronautical field.Scientific reports · 2022Article
- EIS Characterization of Ti Alloys in Relation to Alloying Additions of Ta.Materials (Basel, Switzerland) · 2022Article
- Intraperitoneal injections of copper ferrite nanoparticles disturb blood, plasma, and antioxidant parameters of Wistar rats in a sex-specific manner.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Are Titania Photocatalysts and Titanium Implants Safe? Review on the Toxicity of Titanium Compounds.Nanomaterials (Basel, Switzerland) · 2020Review
- Synthesis, characterization, and biocompatibility of lanthanum titanate nanoparticles in albino mice in a sex-specific manner.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Titanium, Aluminum and Vanadium (Ti 6Al 4V) alloy are frequently used as surgical implant but regarding their compatibility in living systems is limited. Ti 6Al 4V was prepared from high purity constituents and Ti 6Al 4V alloy powder (25 mg/ml solvent/Kg body weight) was gavaged to albino mice for 8 days. A saline treated control group was maintained in parallel. A series of behavioral (rota rod, light and dark box, open field and novel object) test performance, complete blood count, selected serum (HDL cholesterol, LDL cholesterol, creatinine, cholesterol and triglycerides) parameters, antioxidant metabolites from vital organs (superoxide dismutase, catalase and lipid peroxidation) from vital organs and body weight were determined in both treatments. It was observed that rota rod test performance in male (P = 0.05) and novel object recognition capability in female mice (P = 0.04) were significantly reduced as compared to their respective control groups. Body weight, complete blood count and studied serum parameters remained unaffected when compared between two treatments of both genders. Concentration of superoxide dismutase in liver (P = 0.008), heart (P = 0.01) and lungs (P = 0.05) was significantly elevated while catalase concentration in liver (P = 0.001) was significantly decreased in female albino mice that were exposed to 25 mg/ml solvent/kg body weight of Ti 6 A l 4 V alloy powder. In case of male albino mice, superoxide dismutase concentration in lungs was reduced (P = 0.05) in mice exposed to Ti 6 A l 4 V alloy powder. In conclusion, our results indicated that short term exposure to 25 mg/ml solvent/Kg body weight of Ti-6Al-4V alloy powder supplementation had adversely affected selected aspects of behavior of albino mice in a gender specific manner. Analysis of antioxidant parameters in vital organs has demonstrated that the applied dose of Ti-6Al-4V alloy powder can disturb the H₂O₂ associated metabolic pathways in albino mice, especially in female mice. As this alloy is part of surgical implants, so we recommend that their effects in living systems must be extensively explored under variable dose and exposure time conditions to know more about their biocompatibility.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.