Evidence map›Paper›PMID 29984165›Full record

ArticleNeuroImage. Clinical2018

Diffusion MRI tractography for improved transcranial MRI-guided focused ultrasound thalamotomy targeting for essential tremor.

Qiyuan Tian, Max Wintermark, W Jeffrey Elias, Pejman Ghanouni, Casey H Halpern, Jaimie M Henderson, Diane S Huss, Maged Goubran, Christian Thaler, Raag Airan and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Magnetic Resonance-Guided Focused Ultrasound Thalamotomy Rebalances Atypical Functional Hierarchy in Patients with Essential Tremor.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Qiyuan TianDepartment of Electrical Engineering, Stanford University, Stanford, CA, United States; Department of Radiology, Stanford University, Stanford, CA, United States. Electronic address: qytian@stanford.edu.
Max WintermarkDepartment of Radiology, Stanford University, Stanford, CA, United States.
W Jeffrey EliasDepartment of Neurosurgery, University of Virginia, Charlottesville, VA, United States.
Pejman GhanouniDepartment of Radiology, Stanford University, Stanford, CA, United States.
Casey H HalpernDepartment of Neurosurgery, Stanford University, Stanford, CA, United States.
Jaimie M HendersonDepartment of Neurosurgery, Stanford University, Stanford, CA, United States.
Diane S HussDepartment of Physical Therapy, University of Virginia, Charlottesville, VA, United States.
Maged GoubranDepartment of Radiology, Stanford University, Stanford, CA, United States.
Christian ThalerDepartment of Radiology, Stanford University, Stanford, CA, United States; Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Raag AiranDepartment of Radiology, Stanford University, Stanford, CA, United States.
Michael ZeinehDepartment of Radiology, Stanford University, Stanford, CA, United States.
Kim Butts PaulyDepartment of Electrical Engineering, Stanford University, Stanford, CA, United States; Department of Radiology, Stanford University, Stanford, CA, United States.
Jennifer A McNabDepartment of Radiology, Stanford University, Stanford, CA, United States.

Funding

Training and DisseminationP41EB015891 · NIBIB · STANFORD UNIVERSITY · PI GLOVER, GARY H · 2012 to 2019
$10.7M
Foundations of MRI Corticography for mesoscale organization and neuronal circuitryR01MH111444 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI FEINBERG, DAVID ALAN · 2016 to 2020
$5.1M
Integration of Diffusion MRI Fiber Tracking and CLARITY 3D Histology for Improved Neurosurgical TargetingR01NS095985 · NINDS · STANFORD UNIVERSITY · PI Jennifer A McNab · 2016 to 2026
$3.8M
Next Generation 7T MRI Platform Upgrade with Parallel Transmit CapabilitiesS10RR026351 · NCRR · STANFORD UNIVERSITY · PI RUTT, BRIAN KEITH · 2011 to 2011
$600k
NCRR NIH HHS S10 RR026351NIBIB NIH HHS P41 EB015891NIMH NIH HHS R01 MH111444NINDS NIH HHS R01 NS095985
6 · The paper itself

Abstract

Purpose: To evaluate the use of diffusion magnetic resonance imaging (MRI) tractography for neurosurgical guidance of transcranial MRI-guided focused ultrasound (tcMRgFUS) thalamotomy for essential tremor (ET). Materials and methods: Eight patients with medication-refractory ET were treated with tcMRgFUS targeting the ventral intermediate nucleus (Vim) of the thalamus contralateral to their dominant hand. Diffusion and structural MRI data and clinical evaluations were acquired pre-treatment and post-treatment. To identify the optimal target location, tractography was performed on pre-treatment diffusion MRI data between the treated thalamus and the hand-knob region of the ipsilateral motor cortex, the entire ipsilateral motor cortex and the contralateral dentate nucleus. The tractography-identified locations were compared to the lesion location delineated on 1 year post-treatment T Results: The probabilistic tractography was consistent from subject-to-subject and followed the expected anatomy of the thalamocortical radiation and the dentatothalamic tract. Higher overlap between the tractography-identified location and the tcMRgFUS treatment-induced lesion highly correlated with better treatment outcome (r = -0.929, -0.75, -0.643, p = 0.00675, 0.0663, 0.139 for the tractography between the treated thalamus and the hand-knob region of the ipsilateral motor cortex, the entire ipsilateral motor cortex and the contralateral dentate nucleus, respectively, at 1 year post-treatment). The correlation for the tractography between the treated thalamus and the hand-knob region of the ipsilateral motor cortex is the highest for all time points (r = -0.719, -0.976, -0.707, -0.929, p = 0.0519, 0.000397, 0.0595, 0.00675 at 1 month, 3 months, 6 months and 1 year post-treatment, respectively). Conclusion: Our data support the use of diffusion tractography as a complementary approach to current targeting methods for tcMRgFUS thalamotomy.

Indexed as

Magnetic Resonance ImagingUltrasonic TherapyBrain MappingDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingEssential TremorHumansMotor CortexThalamusTreatment OutcomeDiffusion tractographyEssential tremorNeurosurgical targetingThalamotomyTranscranial MRI-guided focused ultrasoundVentral intermediate nucleus

Identifiers

PMID29984165
PMCPMC6029558

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.