Evidence map›Paper›PMID 29984164›Full record

ArticleNeuroImage. Clinical2018

Beta-band oscillations in the supplementary motor cortex are modulated by levodopa and associated with functional activity in the basal ganglia.

Jae Woo Chung, Roxana G Burciu, Edward Ofori, Stephen A Coombes, Evangelos A Christou, Michael S Okun, Christopher W Hess, David E Vaillancourt

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Deep Learning-Based Decoding and Feature Visualization of Motor Imagery Speeds From EEG Signals.IEEE open journal of engineering in medicine and biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Dysfunction of motor cortices in Parkinson's disease.Cerebral cortex (New York, N.Y. : 1991) · 2024
    Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jae Woo ChungDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA.
Roxana G BurciuDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, DE, USA.
Edward OforiCollege of Health Solutions, Arizona State University, Phoenix, AZ, USA.
Stephen A CoombesDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA.
Evangelos A ChristouDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA; Department of Physical Therapy, University of Florida, Gainesville, FL, USA.
Michael S OkunDepartment of Neurology and Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL, USA.
Christopher W HessDepartment of Neurology and Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL, USA.
David E VaillancourtDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA; Department of Neurology and Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL, USA; Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA. Electronic address: vcourt@ufl.edu.
University of Florida · USArizona State University · USUniversity of Delaware · US

Funding

Scaling and Sequencing Motor Output in Humans: fMRI StudyR01NS052318 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI VAILLANCOURT, DAVID E · 2005 to 2020
$6.0M
Non-Invasive Markers of Neurodegeneration in Movement DisordersR01NS075012 · NINDS · UNIVERSITY OF FLORIDA · PI LI, YUQING, VAILLANCOURT, DAVID E · 2012 to 2022
$4.1M
Interdisciplinary Training in Movement Disorders and NeurorestorationT32NS082168 · NINDS · UNIVERSITY OF FLORIDA · PI Melissa Jo Armstrong, David E Vaillancourt · 2015 to 2026
$2.8M
NINDS NIH HHS R01 NS052318NINDS NIH HHS R01 NS075012NINDS NIH HHS T32 NS082168
6 · The paper itself

Abstract

We investigated the effect of acute levodopa administration on movement-related cortical oscillations and movement velocity in Parkinson's disease (PD). Patients with PD on and off medication and age- and sex-matched healthy controls performed a ballistic upper limb flexion movement as fast and accurately as possible while cortical oscillations were recorded with high-density electroencephalography. Patients off medication were also studied using task-based functional magnetic resonance imaging (fMRI) using a force control paradigm. Percent signal change of functional activity during the force control task was calculated for the putamen and subthalamic nucleus (STN) contralateral to the hand tested. We found that patients with PD off medication had an exaggerated movement-related beta-band (13-30 Hz) desynchronization in the supplementary motor area (SMA) compared to controls. In PD, spectral power in the beta-band was correlated with movement velocity. Following an acute dose of levodopa, we observed that the beta-band desynchronization in the SMA was reduced in PD, and was associated with increased movement velocity and increased voltage of agonist muscle activity. Further, using fMRI we found that the functional activity in the putamen and STN in the off medication state, was related to how responsive that cortical oscillations in the SMA of PD were to levodopa. Collectively, these findings provide the first direct evaluation of how movement-related cortical oscillations relate to movement velocity during the ballistic phase of movement in PD and demonstrate that functional brain activity in the basal ganglia pathways relate to the effects of dopaminergic medication on cortical neuronal oscillations during movement.

Indexed as

AdultAgedAntiparkinson AgentsBasal GangliaDeep Brain StimulationFemaleHumansLevodopaMagnetic Resonance ImagingMaleMiddle AgedMotor CortexMovementParkinson DiseasePhysical Therapy ModalitiesSubthalamic NucleusAntiparkinson AgentsLevodopaBallistic movementsBOLD, blood oxygen level dependentDBS, deep brain stimulationECoG, electrocorticographyEEGEEG, electroencephalographyEMG, electromyographyERSP, event-related power spectral perturbationFDR, false discovery ratefMRIfMRI, functional magnetic resonance imagingHC, healthy controlICA, independent component analysisiEMG, integrated electromyographyLevodopaLFP, local field potentialM1, primary motor cortexMDS-UPDRS, Movement Disorder Society Unified Parkinson's Disease Rating ScaleMEG, magnetoencephalographyMoCA, Montreal Cognitive AssessmentMPA, measure projection analysisMVC, maximum voluntary contractionParkinson's diseasePD-OFF, off medication (levodopa) dayPD-ON, on medication (levodopa) dayPD, Parkinson's diseasePET, positron emission tomographyrCBF, regional cerebral blood flowROI, regions of interestS1, primary somatosensory cortexSMA, supplementary motor areaSNc, substantia nigra pars compactaSTN, subthalamic nucleusSupplementary motor area

Identifiers

PMID29984164
PMCPMC6029579
OpenAlexW2803879351

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.