ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2018
A Multimaterial Scaffold With Tunable Properties: Toward Bone Tissue Repair.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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Who cites it
81 citing papers in PubMed, 367 citations in OpenAlex.
- Photocontrolled biomimetic PEEK scaffold with black phosphorus-strontium ion cascade release for vascularized bone regeneration.Materials today. Bio · 2026Article
- Dual reinforcement of PEKK composites with hydroxyapatite and silicon nitride nanowires for enhanced mechanical, tribological, antibacterial, and osteogenic performance.Journal of nanobiotechnology · 2026Article
- Engineering macromolecular crowding-driven amyloid-mineral hybrid scaffolds for enhanced bone regeneration.Bioactive materials · 2026Article
- Application of Patient-Specific PCL/Case reports in dentistry · 2026Article
- Bifunctional 3D-printed PEEK scaffolds incorporating hydrogel-encapsulated magnesium-quinone nanosheets for antibacterial activity and mandibular bone regeneration.Materials today. Bio · 2025Article
- 3D-Printed Multidimensional Bionic Mg-MC/PLGA Composite for Tailored Repair of Segmental Long Bone Defects.Advanced healthcare materials · 2025Article
- TPMS-Gyroid Scaffold-Mediated Up-Regulation of ITGB1 for Enhanced Cell Adhesion and Immune-Modulatory Osteogenesis.Advanced healthcare materials · 2025Article
- Sequential simulation of regeneration-specific microenvironments using scaffolds loaded with nanoplatelet vesicles enhances bone regeneration.Bioactive materials · 2025Article
- Programmable DNA-based biomaterials for bone tissue engineering.Fundamental research · 2025Review
- Modulating cell adhesion and infiltration in advanced scaffold designs based on PLLA fibers with rGO and MXene (TiMaterials today. Bio · 2025Article
- Structurally and Functionally Adaptive Biomimetic Periosteum: Materials, Fabrication, and Construction Strategies.Exploration (Beijing, China) · 2025Review
- Copper doped bioactive glass promotes matrix vesicles-mediated biomineralization via osteoblast mitophagy and mitochondrial dynamics during bone regeneration.Bioactive materials · 2025Article
- Construction of a 3D Degradable PLLA/β-TCP/CS Scaffold for Establishing an Induced Membrane Inspired by the Modified Single-Stage Masquelet Technique.ACS biomaterials science & engineering · 2025Article
- Oriented Cortical-Bone-Like Silk Protein Lamellae Effectively Repair Large Segmental Bone Defects in Pigs.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Review
- Surface modification of polyetheretherketone for boosted osseointegration: A review.Biomaterials translational · 2025Review
- Biomimetic materials: a promising strategy for periodontal tissue engineering and regeneration.Frontiers in bioengineering and biotechnology · 2025Review
- Review
- Preparation and properties of silver-carrying nano-titanium dioxide antimicrobial agents and silicone composite.Scientific reports · 2024Article
- Therapeutic impacts of GNE‑477‑loaded HInternational journal of molecular medicine · 2024Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyetheretherketone (PEEK)/β-tricalcium phosphate (β-TCP) scaffolds are expected to be able to combine the excellent mechanical strength of PEEK and the good bioactivity and biodegradability of β-TCP. While PEEK acts as a closed membrane in which β-TCP is completely wrapped after the melting/solidifying processing, the PEEK membrane degrades very little, hence the scaffolds cannot display bioactivity and biodegradability. The strategy reported here is to blend a biodegradable polymer with PEEK and β-TCP to fabricate multi-material scaffolds via selective laser sintering (SLS). The biodegradable polymer first degrades and leaves caverns on the closed membrane, and then the wrapped β-TCP is exposed to body fluid. In this study, poly(l-lactide) (PLLA) is adopted as the biodegradable polymer. The results show that large numbers of caverns form on the membrane with the degradation of PLLA, enabling direct contact between β-TCP and body fluid, and allowing for their ion-exchange. As a consequence, the scaffolds display the bioactivity, biodegradability and cytocompatibility. Moreover, bone defect repair studies reveal that new bone tissues grow from the margin towards the center of the scaffolds from the histological analysis. The bone defect region is completely connected to the host bone end after 8 weeks of implantation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.