ArticleBiomedical optics express2018
Fiber-based visible and near infrared optical coherence tomography (vnOCT) enables quantitative elastic light scattering spectroscopy in human retina.
Article in Biomedical optics express, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Ultrabroadband OCT for simultaneous visible and near-infrared light imaging of the mouse retina.Biomedical optics express · 2026Article
- Visible-light optical coherence tomography and its applications.Neurophotonics · 2025Review
- Macular Oxygen Saturation in Glaucoma Using Retinal Oximetry of Visible Light Optical Coherence Tomography: A Pilot Study.Translational vision science & technology · 2025Article
- Lightweight Retinal Layer Segmentation With Global Reasoning.IEEE transactions on instrumentation and measurement · 2024Article
- Macular Oxygen Saturation in Glaucoma Using Retinal Oximetry of Visible Light Optical Coherence Tomography.medRxiv : the preprint server for health sciences · 2023Article
- Diverse Research Teams and Underrepresented Groups in Clinical Studies.JAMA ophthalmology · 2023Article
- Deep learning network for parallel self-denoising and segmentation in visible light optical coherence tomography of the human retina.Biomedical optics express · 2023Article
- Visible Light Optical Coherence Tomography of Peripapillary Retinal Nerve Fiber Layer Reflectivity in Glaucoma.Translational vision science & technology · 2022Article
- Simultaneous visible light optical coherence tomography and near infrared OCT angiography in retinal pathologies: A case study.Experimental biology and medicine (Maywood, N.J.) · 2022Article
- The Development and Clinical Application of Innovative Optical Ophthalmic Imaging Techniques.Frontiers in medicine · 2022Review
- Global and Regional Damages in Retinal Ganglion Cell Axon Bundles Monitored Non-Invasively by Visible-Light Optical Coherence Tomography Fibergraphy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Article
- Water wavenumber calibration for visible light optical coherence tomography.Journal of biomedical optics · 2020Article
- Visible light optical coherence tomography angiography (vis-OCTA) facilitates local microvascular oximetry in the human retina.Biomedical optics express · 2020Article
- Hyperspectral optical coherence tomography for in vivo visualization of melanin in the retinal pigment epithelium.Journal of biophotonics · 2019Article
- Longitudinal detection of retinal alterations by visible and near-infrared optical coherence tomography in a dexamethasone-induced ocular hypertension mouse model.Neurophotonics · 2019Article
- Monitoring retinal responses to acute intraocular pressure elevation in rats with visible light optical coherence tomography.Neurophotonics · 2019Article
- Light scattering methods for tissue diagnosis.Optica · 2019Article
- Quantitative quality-control metrics forBiomedical optics express · 2019Article
- The path to clinical translation for visible light optical coherence tomography in retinal imaging.Taiwan journal of ophthalmologyReview
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Elastic light scattering spectroscopy (ELSS) has been proven a powerful method in measuring tissue structures with exquisite nanoscale sensitivity. However, ELSS contrast in the living human retina has been relatively underexplored, primarily due to the lack of imaging tools with a large spectral bandwidth. Here, we report a simple all fiber-based setup to implement dual-channel visible and near infrared (NIR) optical coherence tomography (vnOCT) for human retinal imaging, bridging over a 300nm spectral gap. Remarkably, the fiber components in our vnOCT system support single-mode propagation for both visible and NIR light, both of which maintain excellent interference efficiencies with fringe visibility of 97% and 90%, respectively. The longitudinal chromatic aberration from the eye is corrected by a custom-designed achromatizing lens. The elegant fiber-based design enables simultaneous imaging for both channels and allows comprehensive ELSS analysis on several important anatomical layers, including nerve fiber layer, outer segment of the photoreceptors and retinal pigment epithelium. This vnOCT platform and method of ELSS analysis open new opportunities in understanding structure-function relationship in the human retina and in exploring new biomarkers for retinal diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.