Evidence map›Paper›PMID 29984093›Full record

ArticleBiomedical optics express2018

Prediction of the anti-glioma therapeutic effects of temozolomide through

Li Li, Yang Du, Dehui Xiang, Liang Chen, Zhifeng Shi, Jie Tian, Xinjian Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Li LiSchool of Electronic and Information Engineering, Soochow University, No. 1 Ten Azusa Street, Suzhou, 215006, China.
Yang DuCAS Key Laboratory of Molecular Imaging, The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, No. 95 Zhongguancun East Road, Haidian District, Beijing, 100190, China.
Dehui XiangSchool of Electronic and Information Engineering, Soochow University, No. 1 Ten Azusa Street, Suzhou, 215006, China.
Liang ChenDepartment of Neurosurgery, Huashan Hospital, Fudan University, No. 12 Urumqi Road, Jingan District, Shanghai, 200040, China.
Zhifeng ShiDepartment of Neurosurgery, Huashan Hospital, Fudan University, No. 12 Urumqi Road, Jingan District, Shanghai, 200040, China.
Jie TianCAS Key Laboratory of Molecular Imaging, The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, No. 95 Zhongguancun East Road, Haidian District, Beijing, 100190, China.
Xinjian ChenSchool of Electronic and Information Engineering, Soochow University, No. 1 Ten Azusa Street, Suzhou, 215006, China.
Chinese Academy of Sciences · CNFudan University · CNSoochow University · CNUniversité Paris-Sud · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently, there is no effective way to assess the therapeutic response of temozolomide (TMZ) for the glioma. In this study, the human U87MG-fLuc glioma animal models were set up and the antitumor efficacy of TMZ was evaluated using bioluminescence imaging (BLI) and MRI. Then, bioluminescence tomography (BLT) was reconstructed using an adaptive sparsity matching pursuit (ASMP) algorithm. Second, the expression level of the MMP-750 probe was examined with or without TMZ treatment using FMI. Third, the expression of MMP2 and MMP3 was specifically examined after treatment. The results showed that TMZ effectively inhibited glioma growth. The targeted imaging of MMP-750 was decreased during the treatment of glioma with TMZ. Moreover, the MMP2 and MMP3 expression was found to correlate with the inhibition effect of TMZ. Our study indicated that the therapeutic effects of TMZ can be effectively evaluated at an early stage using molecular imaging, and MMP targeting the fluorescence probe could be utilized for the prediction and assessment of the therapeutic effects of TMZ.

Indexed as

(110.6955) Tomographic imaging(170.3880) Medical and biological imaging(170.4580) Optical diagnostics for medicine(170.6280) Spectroscopy, fluorescence and luminescence

Identifiers

PMID29984093
PMCPMC6033562
OpenAlexW2809105046

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.