Evidence map›Paper›PMID 29984087›Full record

ArticleBiomedical optics express2018

Realistic simulation and experiment reveals the importance of scatterer microstructure in optical coherence tomography image formation.

Paweł Ossowski, Andrea Curatolo, David D Sampson, Peter R T Munro

Abstract read
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In one paragraph

Article in Biomedical optics express, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Paweł OssowskiInstitute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University Grudziadzka 5, 87-100 Torun, Poland.
Andrea CuratoloCurrent address: Instituto de Optica "Daza de Valdés", Consejo Superior de Investigaciones Cientifícas (IO, CSIC), Madrid, Spain.
David D SampsonOptical + Biomedical Engineering Laboratory, School of Electrical, Electronic and Computer Engineering, The University of Western Australia, Perth, Western Australia 6009, Australia.
Peter R T MunroUniversity of Surrey, Guildford GU2 7XH, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Realistic simulation of image formation in optical coherence tomography, based on Maxwell's equations, has recently been demonstrated for sample volumes of practical significance. Yet, there remains a limitation whereby reducing the size of cells used to construct a computational grid, thus allowing for a more realistic representation of scatterer microstructure, necessarily reduces the overall sample size that can be modelled. This is a significant problem since, as is well known, the microstructure of a scatterer significantly influences its scattering properties. Here we demonstrate that an optimized scatterer design can overcome this problem resulting in good agreement between simulated and experimental images for a structured phantom. This approach to OCT image simulation allows for image formation for biological tissues to be simulated with unprecedented realism.

Indexed as

(050.1755) Computational electromagnetic methods(110.4500) Optical coherence tomography(170.3660) Light propagation in tissues(180.0180) Microscopy

Identifiers

PMID29984087
PMCPMC6033572

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.