Evidence map›Paper›PMID 29983857›Full record

ArticleOxidative medicine and cellular longevity2018

Transient Receptor Potential Canonical Channels 4 and 5 Mediate

Domingos M S Pereira, Saulo J F Mendes, Khadija Alawi, Pratish Thakore, Aisah Aubdool, Nágila C F Sousa, João F R da Silva, José A Castro, Ione C P Pereira, Luís C N Silva and 7 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Distribution of TRPC5 in the human lung: A study in body donors.Experimental and therapeutic medicine · 2024
    Article
  2. The Role of TRP Channels in Sepsis and Colitis.International journal of molecular sciences · 2024
    Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 2 countries.

Domingos M S PereiraPrograma de Pós-graduação, Universidade Ceuma, Rua dos Castanheiros, no 1, Renascença II, São Luís, MA, Brazil.
Saulo J F MendesPrograma de Pós-graduação, Universidade Ceuma, Rua dos Castanheiros, no 1, Renascença II, São Luís, MA, Brazil.
Khadija AlawiVascular Biology and Inflammation Section, BHF Cardiovascular Centre of Excellence, King's College London, Waterloo Campus, London, UK.ORCID 0000-0002-9208-9131
Pratish ThakoreVascular Biology and Inflammation Section, BHF Cardiovascular Centre of Excellence, King's College London, Waterloo Campus, London, UK.
Aisah AubdoolVascular Biology and Inflammation Section, BHF Cardiovascular Centre of Excellence, King's College London, Waterloo Campus, London, UK.
Nágila C F SousaPrograma de Pós-graduação, Universidade Ceuma, Rua dos Castanheiros, no 1, Renascença II, São Luís, MA, Brazil.
João F R da SilvaPrograma de Pós-graduação, Universidade Ceuma, Rua dos Castanheiros, no 1, Renascença II, São Luís, MA, Brazil.
José A CastroPrograma de Pós-graduação, Universidade Ceuma, Rua dos Castanheiros, no 1, Renascença II, São Luís, MA, Brazil.
Ione C P PereiraPrograma de Pós-graduação, Universidade Ceuma, Rua dos Castanheiros, no 1, Renascença II, São Luís, MA, Brazil.
Luís C N SilvaPrograma de Pós-graduação, Universidade Ceuma, Rua dos Castanheiros, no 1, Renascença II, São Luís, MA, Brazil.
Marcos A G GrisottoPrograma de Pós-graduação, Universidade Ceuma, Rua dos Castanheiros, no 1, Renascença II, São Luís, MA, Brazil.ORCID 0000-0003-2077-7979
Valério Monteiro-NetoPrograma de Pós-graduação, Universidade Ceuma, Rua dos Castanheiros, no 1, Renascença II, São Luís, MA, Brazil.ORCID 0000-0003-2868-1314
Soraia K P CostaDepartamento de Farmacologia, Universidade de São Paulo, Av. Prof. Lineu Prestes, Butantan, SP, Brazil.
Robson da CostaWolfson Centre for Age-Related Diseases, King's College London, London Bridge, London, UK.
João B CalixtoCentro de Inovação e Ensaios Pré-Clínicos - CIEnP, Av. Luiz Boiteux Piazza, no 1302 - Cachoeira do Bom Jesus, Florianópolis, SC, Brazil.
Susan D BrainVascular Biology and Inflammation Section, BHF Cardiovascular Centre of Excellence, King's College London, Waterloo Campus, London, UK.
Elizabeth S FernandesPrograma de Pós-graduação, Universidade Ceuma, Rua dos Castanheiros, no 1, Renascença II, São Luís, MA, Brazil.ORCID 0000-0002-0567-2514
Universidade Ceuma · BRKing's College London · GBUniversidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thioredoxin plays an essential role in bacterial antioxidant machinery and virulence; however, its regulatory actions in the host are less well understood. Reduced human Trx activates transient receptor potential canonical 5 (TRPC5) in inflammation, but there is no evidence of whether these receptors mediate bacterial thioredoxin effects in the host. Importantly, TRPC5 can form functional complexes with other subunits such as TRPC4. Herein,

Indexed as

AnimalsEscherichia coliHydrogen PeroxideIndolesLipopolysaccharidesMaleMiceMice, Inbred C57BLMice, KnockoutNitric OxidePhagocytosisPiperidinesSystemic Inflammatory Response SyndromeThioredoxinsTRPC Cation ChannelsVirulenceHydrogen PeroxideIndolesLipopolysaccharidesML 204Nitric OxidePiperidinesThioredoxinsTRPC4 ion channelTrpc5 protein, mouseTRPC Cation Channels

Identifiers

PMID29983857
PMCPMC6015690
OpenAlexW2807003575

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.