Evidence map›Paper›PMID 29983834›Full record

ArticleClinical epigenetics2018

Epigenetic signature of preterm birth in adult twins.

Qihua Tan, Shuxia Li, Morten Frost, Marianne Nygaard, Mette Soerensen, Martin Larsen, Kaare Christensen, Lene Christiansen

Open access · goldAbstract readTwin Study
In one paragraph

Article in Clinical epigenetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Medicina (Kaunas, Lithuania) · 2024
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. An Emerging Role for Epigenetics in Cerebral Palsy.Journal of personalized medicine · 2021
    Review
  14. Article
  15. Alteration of the brain methylation landscape following postnatal inflammatory injury in rat pups.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
  16. Epigenetic biomarkers and preterm birth.Environmental epigenetics · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Qihua Tan1Epidemiology and Biostatistics, Department of Public Health, Faculty of Health Science, University of Southern Denmark, J. B. Winsløws Vej 9B, DK-5000 Odense, Denmark.ORCID 0000-0003-3194-0030
Shuxia Li2Unit of Human Genetics, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Morten Frost3Department of Endocrinology, Odense University Hospital, Odense, Denmark.
Marianne Nygaard1Epidemiology and Biostatistics, Department of Public Health, Faculty of Health Science, University of Southern Denmark, J. B. Winsløws Vej 9B, DK-5000 Odense, Denmark.
Mette Soerensen1Epidemiology and Biostatistics, Department of Public Health, Faculty of Health Science, University of Southern Denmark, J. B. Winsløws Vej 9B, DK-5000 Odense, Denmark.
Martin Larsen2Unit of Human Genetics, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Kaare Christensen1Epidemiology and Biostatistics, Department of Public Health, Faculty of Health Science, University of Southern Denmark, J. B. Winsløws Vej 9B, DK-5000 Odense, Denmark.
Lene Christiansen1Epidemiology and Biostatistics, Department of Public Health, Faculty of Health Science, University of Southern Denmark, J. B. Winsløws Vej 9B, DK-5000 Odense, Denmark.
University of Southern Denmark · DKOdense University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Preterm birth is a leading cause of perinatal mortality and long-term health consequences. Epigenetic mechanisms may have been at play in preterm birth survivors, and these could be persistent and detrimental to health later in life. Methods: We performed a genome-wide DNA methylation profiling in adult twins of premature birth to identify genomic regions under differential epigenetic regulation in 144 twins with a median age of 33 years (age range 30-36). Results: Association analysis detected three genomic regions annotated to the Conclusion: We have found novel evidence associating premature delivery with epigenetic modification of important genes/pathways and revealed that preterm birth, as an early life event, could be related to differential methylation regulation patterns observable in adults and even at high ages which could potentially mediate susceptibility to age-related diseases and adult health.

Indexed as

DNA MethylationAdultAgedAged, 80 and overCpG IslandsElectron Transport Complex IIEpigenesis, GeneticFemaleGlutathione TransferaseHumansMaleMiddle AgedNerve Tissue ProteinsPremature BirthTwins, MonozygoticElectron Transport Complex IIglutathione S-transferase T1Glutathione TransferaseNerve Tissue ProteinsSDHA protein, humanTAGLN3 protein, humanAdultsEpigeneticsEpigenome-wide association studyPreterm birthTwins

Identifiers

PMID29983834
PMCPMC6020425
OpenAlexW2547303935

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.