Evidence map›Paper›PMID 29983793›Full record

ArticleOpen access Macedonian journal of medical sciences2018

Serum Markers of Iron Metabolism in Chronic Liver Diseases.

Mariana Penkova Radicheva, Albena Nikolaeva Andonova, Hristina Tancheva Milcheva, Nadejda Gospodinova Ivanova, Silviya Georgieva Kyuchukova, Mima Stefanova Nikolova, Agdalena Stefanova Platikanova

Open access · diamondAbstract read
In one paragraph

Article in Open access Macedonian journal of medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Mariana Penkova Radicheva"Trakia University", Stara Zagora, Bulgaria.
Albena Nikolaeva Andonova"Trakia University", Stara Zagora, Bulgaria.
Hristina Tancheva Milcheva"Trakia University", Stara Zagora, Bulgaria.
Nadejda Gospodinova Ivanova"Trakia University", Stara Zagora, Bulgaria.
Silviya Georgieva Kyuchukova"Trakia University", Stara Zagora, Bulgaria.
Mima Stefanova Nikolova"Trakia University", Stara Zagora, Bulgaria.
Agdalena Stefanova Platikanova"Trakia University", Stara Zagora, Bulgaria.
Trakia University · BG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDisorders in the metabolism of iron in the direction of iron overload are observed not only in primary hemochromatosis but also in some chronic liver diseases other aetiology. Elevation of serum iron, ferritin and transferrin saturation is reported in nonalcoholic fatty liver disease and alcohol, chronic hepatitis C and liver cirrhosis.

aimAim of the study was to evaluate and compare the frequency of the iron serum markers in patients with various chronic liver diseases. MATERIAL AND

methodsThe study included a total of 246 persons -186 patients with chronic liver disease without cirrhosis (-115 men, women -71; average age of 50.41 ± 12.85, from 23 to 77 years) and 60 healthy controls (-30 men, women -30, middle-aged 50.50 ± 11.31, from 29 to 83 years). Medical history, physical examination and demographic data including height, weight, laboratory and instrumental studies were performed.

resultsThe highest incidence of elevated serum iron, transferrin saturation and ferritin and decreased serum hepcidin found in cases of alcoholic liver disease (ALD), nonalcoholic fatty liver disease (NAFLD) and chronic hepatitis C (CHC).

conclusionFinally, analysis of the changes in serum markers of iron metabolism shows that the difference between healthy and sick with liver disease is primarily due to changes in alcoholic and nonalcoholic fatty liver disease, particularly steatohepatitis, and chronic hepatitis C.

Indexed as

Chronic liver diseaseSerum ferritinSerum ironSteatosisTransferrin saturation

Identifiers

PMID29983793
PMCPMC6026417
OpenAlexW2807929669

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.