Evidence map›Paper›PMID 29983750›Full record

ArticleGut pathogens2018

ESBL-plasmid carriage in

Amit Ranjan, Julia Scholz, Torsten Semmler, Lothar H Wieler, Christa Ewers, Stefanie Müller, Derek J Pickard, Peter Schierack, Karsten Tedin, Niyaz Ahmed and 2 more

Open access · goldAbstract read
In one paragraph

Article in Gut pathogens, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. A plasmid with theMicrobiology (Reading, England) · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. (Antibiotic-Resistant)Environmental science & technology · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Why do plasmids manipulate the expression of bacterial phenotypes?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Review
  14. Article
  15. Article
  16. HypervirulentInternational journal of molecular sciences · 2021
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 3 countries.

Amit Ranjan1Institute of Microbiology and Epizootics, Veterinary Faculty, Freie Universität Berlin, Robert-von-Ostertag Str. 7-13, 14163 Berlin, Germany.
Julia Scholz1Institute of Microbiology and Epizootics, Veterinary Faculty, Freie Universität Berlin, Robert-von-Ostertag Str. 7-13, 14163 Berlin, Germany.
Torsten Semmler3Robert Koch Institute, Berlin, Germany.
Lothar H Wieler3Robert Koch Institute, Berlin, Germany.
Christa Ewers4Institute of Hygiene and Infectious Diseases of Animals, Veterinary Faculty, Justus-Liebig-Universität Giessen, Giessen, Germany.
Stefanie Müller1Institute of Microbiology and Epizootics, Veterinary Faculty, Freie Universität Berlin, Robert-von-Ostertag Str. 7-13, 14163 Berlin, Germany.
Derek J Pickard5Welcome Trust Sanger Institute, Cambridge, UK.
Peter Schierack6Brandenburgische Technische Universität Cottbus-Senftenberg, Cottbus, Germany.
Karsten Tedin1Institute of Microbiology and Epizootics, Veterinary Faculty, Freie Universität Berlin, Robert-von-Ostertag Str. 7-13, 14163 Berlin, Germany.
Niyaz Ahmed2Pathogen Biology Laboratory, Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, India.
Katharina Schaufler *1Institute of Microbiology and Epizootics, Veterinary Faculty, Freie Universität Berlin, Robert-von-Ostertag Str. 7-13, 14163 Berlin, Germany.
Sebastian Guenther *1Institute of Microbiology and Epizootics, Veterinary Faculty, Freie Universität Berlin, Robert-von-Ostertag Str. 7-13, 14163 Berlin, Germany.
Freie Universität Berlin · DERobert Koch Institute · DEBrandenburg University of Technology Cottbus-Senftenberg · DEUniversität Greifswald · DEUniversity of Giessen · DEUniversity of Hyderabad · INWellcome Sanger Institute · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExtended spectrum beta lactamase (ESBL)-producing extraintestinal pathogenic

methodsTriplets of ESBL-plasmid-carrying wildtype (WT), plasmid-cured variant (PCV) and transformant (T) of five ExPEC strains of ST131 and ST648 were used for bacterial competition experiments with colicin-producing commensal

resultsIn all five strains tested, ESBL-plasmid carriage did not negatively influence

conclusionsOverall, we found no compelling evidence for an increased burden resulting from the carriage of ESBL-plasmids in the absence of antimicrobial selection pressure in the strains of pandemic ST131 and ST648; rather, the possession of certain ESBL-plasmids was beneficial for some strains in regarding competition fitness and serum survival.

Identifiers

PMID29983750
PMCPMC6003029
OpenAlexW2808664572

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.