Evidence map›Paper›PMID 29983589›Full record

ArticleCancer management and research2018

miRNA-146a rs2910164 C>G polymorphism increased the risk of esophagogastric junction adenocarcinoma: a case-control study involving 2,740 participants.

Yu Chen, Weifeng Tang, Chao Liu, Jing Lin, Yafeng Wang, Sheng Zhang, Gang Chen, Xiongwei Zheng

Open access · goldAbstract read
In one paragraph

Article in Cancer management and research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Frontiers in oncology · 2019
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Yu Chen *Department of Medical Oncology, Fujian Cancer Hospital and Fujian Medical University Cancer Hospital, Fuzhou, Fujian Province, China.
Weifeng Tang *Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China.
Chao LiuDepartment of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China.
Jing LinDepartment of Medical Oncology, Fujian Cancer Hospital and Fujian Medical University Cancer Hospital, Fuzhou, Fujian Province, China.
Yafeng WangDepartment of Cardiology, The People's Hospital of Xishuangbanna Dai Autonomous Prefecture, Jinghong, Yunnan Province, China.
Sheng ZhangDepartment of General Surgery, Changzhou No. 3 People's Hospital, Changzhou, Jiangsu Province, China.
Gang ChenFujian Provincial Key Laboratory of Translational Cancer Medicine, Fuzhou, Fujian Province, China, agu1960@fjmu.edu.cn.
Xiongwei ZhengFujian Provincial Key Laboratory of Translational Cancer Medicine, Fuzhou, Fujian Province, China, agu1960@fjmu.edu.cn.
Fujian Medical University · CNFujian Provincial Cancer Hospital · CNAffiliated Hospital of Jiangsu University · CNChangzhou No.2 People's Hospital · CNJiangsu University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe miRNA-146a rs2910164 C>G polymorphism may contribute to the development of cancer. However, the association between this polymorphism and the risk of esophagogastric junction adenocarcinoma (EGJA) remains unclear. In the present study, we carried out a case-control study to explore the potential relationship between miRNA-146a rs2910164 C>G polymorphism and EGJA risk. PATIENTS AND

methodsIn total, 1,063 EGJA patients and 1,677 cancer-free controls were enrolled. The SNPscan

resultsWe found that miRNA-146a rs2910164 C>G polymorphism was associated with a risk of developing EGJA (additive model: adjusted odds ratio (OR), 1.27; 95% CI, 1.07-1.51;

conclusionThe current study highlights that the miRNA-146a rs2910164 C>G polymorphism increased the risk of EGJA in eastern Chinese Han population.

Indexed as

esophagogastric junction adenocarcinomamiRNA-146apolymorphism

Identifiers

PMID29983589
PMCPMC6025765
OpenAlexW2809147530

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.