Evidence map›Paper›PMID 29983566›Full record

ArticleInternational journal of nanomedicine2018

Direct modulation of myelin-autoreactive CD4

Weiya Pei, Xin Wan, Khawar Ali Shahzad, Lei Zhang, Shilong Song, Xiaoxiao Jin, Limin Wang, Chen Zhao, Chuanlai Shen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 47 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Nanotherapeutics and the Brain.Annual review of chemical and biomolecular engineering · 2022
    Review
  13. Review
  14. Physiological and Pathological Factors Affecting Drug Delivery to the Brain by Nanoparticles.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Weiya PeiDepartment of Microbiology and Immunology, Medical School, Southeast University, Nanjing, Jiangsu 210009, China, chuanlaishen@seu.edu.cn.
Xin WanDepartment of Microbiology and Immunology, Medical School, Southeast University, Nanjing, Jiangsu 210009, China, chuanlaishen@seu.edu.cn.
Khawar Ali ShahzadDepartment of Microbiology and Immunology, Medical School, Southeast University, Nanjing, Jiangsu 210009, China, chuanlaishen@seu.edu.cn.
Lei ZhangDepartment of Microbiology and Immunology, Medical School, Southeast University, Nanjing, Jiangsu 210009, China, chuanlaishen@seu.edu.cn.
Shilong SongDepartment of Microbiology and Immunology, Medical School, Southeast University, Nanjing, Jiangsu 210009, China, chuanlaishen@seu.edu.cn.
Xiaoxiao JinDepartment of Microbiology and Immunology, Medical School, Southeast University, Nanjing, Jiangsu 210009, China, chuanlaishen@seu.edu.cn.
Limin WangDepartment of Microbiology and Immunology, Medical School, Southeast University, Nanjing, Jiangsu 210009, China, chuanlaishen@seu.edu.cn.
Chen ZhaoDepartment of Microbiology and Immunology, Medical School, Southeast University, Nanjing, Jiangsu 210009, China, chuanlaishen@seu.edu.cn.
Chuanlai ShenDepartment of Microbiology and Immunology, Medical School, Southeast University, Nanjing, Jiangsu 210009, China, chuanlaishen@seu.edu.cn.
Southeast University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeNumerous nanomaterials have been reported in the treatment of multiple sclerosis or experimental autoimmune encephalomyelitis (EAE). But most of these nanoscale therapeutics deliver myelin antigens together with toxins or cytokines and underlay the cellular uptake and induction of tolerogenic antigen-presenting cells by which they indirectly induce T cell tolerance. This study focuses on the on-target and direct modulation of myelin-autoreactive T cells and combined use of multiple regulatory molecules by generating a tolerogenic nanoparticle. MATERIALS AND

methodsPoly(lactic-co-glycolic acid) nanoparticles (PLGA-NPs) were fabricated by co-coupling MOG

resultsFour infusions of the tNPs durably ameliorated EAE with a marked reduction of clinical score, neuroinflammation and demyelination. They were distributed in secondary lymphoid tissues, various organs and brain after intravenous injection, with retention over 36 h, and made contacts with CD4

conclusionOur data suggest a novel therapeutic nanoparticle to directly modulate autoreactive T cells by surface presentation of multiple ligands and paracrine release of cytokine in the antigen-specific combination immunotherapy for T cell-mediated autoimmune diseases.

Indexed as

Immune ToleranceMajor Histocompatibility ComplexAnimalsApoptosisCD47 AntigenCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell ProliferationCytokinesEncephalomyelitis, Autoimmune, ExperimentalFemaleLactic AcidLymphocyte ActivationMice, Inbred C57BLMyelin-Oligodendrocyte GlycoproteinNanoparticlesCD47 AntigenCd47 protein, mouseCytokinesLactic AcidMyelin-Oligodendrocyte GlycoproteinPolyglycolic AcidPolylactic Acid-Polyglycolic Acid Copolymerautoreactive T cellsbiomimetic nanoparticleexperimental autoimmune encephalomyelitisimmunotherapymultiple sclerosismyelin oligodendrocyte glycoprotein

Identifiers

PMID29983566
PMCPMC6027825
OpenAlexW2810831403

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.