Evidence map›Paper›PMID 29983455›Full record

ArticleSynthesis2017

Lewis Acid Mediated Cyclizations: Diastereoselective Synthesis of Six- to Eight-Membered Substituted Cyclic Ethers.

Arun K Ghosh, Anthony J Tomaine, Kelsey E Cantwell

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Synthesis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Dialkyl Ether Formation at High-Valent Nickel.Journal of the American Chemical Society · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Arun K GhoshDepartment of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN, 47907, USA.
Anthony J TomaineDepartment of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN, 47907, USA.
Kelsey E CantwellDepartment of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN, 47907, USA.
Purdue University West Lafayette · USMedicina · PL

Funding

DESIGN AND SYNTHESIS OF NONPEPTIDE PROTEASE INHIBITORSR01GM053386 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GHOSH, ARUN K · 1995 to 2010
$3.7M
NIGMS NIH HHS R01 GM053386
6 · The paper itself

Abstract

Cyclic ethers are widely abundant in natural products. Cyclic ether templates are also utilized in drug design and medicinal chemistry. Although the synthetic processes for this class of compounds have been studied extensively with respect to five- and six-membered rings, medium-sized cyclic ethers are synthetically more challenging due to a variety of factors. Herein, we report our results on the Lewis acid catalyzed synthesis of medium-sized cyclic ethers in a diastereoselective manner.

Indexed as

cyclic etherscyclizationdiastereoselectivityLewis acidsoxacyclesoxepanesoxocenespolycycles

Identifiers

PMID29983455
PMCPMC6034514
OpenAlexW2738736323

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.