ArticleJournal of geriatric oncology2019
Use of a comprehensive frailty assessment to predict morbidity in patients with multiple myeloma undergoing transplant.
Article in Journal of geriatric oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 5 of them syntheses that pooled it.
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Who cites it
47 citing papers in PubMed, 5 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- Falls among geriatric cancer patients: a systematic review and meta-analysis of prevalence and risk across cancer types.BMC geriatrics · 2025Pooled it
- Systematic review of associations between anxiety, depression, and functional/biological aging among cancer survivors.JNCI cancer spectrum · 2024Pooled it
- Associations of frailty with symptoms, and HRQOL in older cancer survivors after cancer treatments: a systematic review and meta-analyses.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Pooled it
- A systematic review of physical function tests as predictors of key clinical outcomes for adults with blood cancers.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Pooled it
- Geriatric assessment in older patients with a hematologic malignancy: a systematic review.Haematologica · 2020Pooled it
- Quality of Life in CAR-T Cell Therapy.Hematology reports · 2026Review
- Assessing physical function in transplantation and CAR-T recipients: expert recommendations from the survivorship, aging and biobehavioral special interest groups of ASTCT.Transplantation and cellular therapy · 2025Review
- Outcomes of older adults and frail patients receiving idecabtagene vicleucel: a CIBMTR study.Blood advances · 2025Article
- Review
- Predictive ability of the Cancer and Aging Research Group chemotherapy toxicity calculator in hematologic malignancy.Journal of geriatric oncology · 2025Article
- Optimizing individualized therapy decision-making in multiple myeloma (MM): integration and impact of the Revised Myeloma Comorbidity Index in the MM-tumor board.Annals of hematology · 2025Article
- Outcomes of frail patients undergoing high-dose chemotherapy and autologous stem cell transplantation for multiple myeloma.British journal of haematology · 2024Article
- Assessment of Mobility Trajectories Using Wearable Inertial Sensors During Autologous Hematopoietic Cell Transplant.Archives of physical medicine and rehabilitation · 2024Article
- Geriatric assessment-guided interventions for older adults with multiple myeloma: A feasibility and acceptability study.Journal of geriatric oncology · 2024Article
- Functional Status Associations With Treatment Receipt and Outcomes Among Older Adults Newly Diagnosed With Multiple Myeloma.JCO clinical cancer informatics · 2024Article
- The FITNESS study: longitudinal geriatric assessment, treatment toxicity, and biospecimen collection to assess functional disability among older adults with lung cancer.Frontiers in aging · 2024Article
- Understanding the health effects of caregiving stress: New directions in molecular aging.Ageing research reviews · 2023Review
- Low Barthel index score is a poor prognostic factor for newly diagnosed multiple myeloma patients.Clinical and experimental medicine · 2023Article
- Different Types of Patient Health Information Associated With Physician Decision-making Regarding Cancer Screening Cessation for Older Adults.JAMA network open · 2023Article
- An objective assessment in newly diagnosed multiple myeloma to avoid treatment complications and strengthen therapy adherence.Haematologica · 2023Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
Multiple myeloma (MM) is a disease of aging adults and autologous stem cell transplant (ASCT) is considered the standard of care. As the population ages a growing number of older adults will undergo ASCT and an objective approach to estimate physiologic reserve and transplant morbidity risk is warranted. Here, we evaluate assess p16
methodsWe prospectively evaluated 100 MM patients for frailty before and after ASCT using a Geriatric Assessment (GA) and collected T-cells for analysis of p16 using a custom nanostring codeset.
resultsPre-transplant physical function was predicative of hospital length of stay (LOS). Each one-unit increase in physical function score, the average LOS decreased by 0.52 days (95% CI, -1.03-0.02); p = .04). Similarly, higher self-report of ADL/IADL (Human Activity Profile was associated with shorter LOS (0.65 less days (95% CI -1.15 to -0.15), p = .01). Patients with anxiety/depression (OR = 1.10 (95% CI 1.00-1.22), p = .056), lower handgrip strength (OR = 0.90 (95% CI 0.82-0.98), p = .02), falls (OR = 1.60 (95% CI 1.07-2.38), p = .02), or weight loss (OR = 5.65 (95% CI 1.17-25.24), p = .03) were more likely to be re-admitted. The estimated EFS at 1-year was 85% (95% CI, 75-91) with median follow-up of 15.7 months. Weight loss was a significant predictor of EFS (HR = 3.13 (95% CI 1.15-8.50), p = .03). Frailty assessment by self-reported fatigue minimally correlated with T-cell p16 expression (r = 0.28; p = .02). Age, Karnofsky Performance Status (KPS), or Hematopoietic cell transplantation-specific Co-Morbidity Index (HCT-CI) did not predict hospital LOS or readmissions.
conclusionsOur data illustrate that a GA can identify individuals with MM who are at greater risk for morbidity following ASCT.
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