Evidence map›Paper›PMID 29983342›Full record

ReviewThe Lancet. Infectious diseases2018

Advancing the public health applications of Chlamydia trachomatis serology.

Sarah C Woodhall, Rachel J Gorwitz, Stephanie J Migchelsen, Sami L Gottlieb, Patrick J Horner, William M Geisler, Catherine Winstanley, Katrin Hufnagel, Tim Waterboer, Diana L Martin and 6 more

Open access · bronzeAbstract readReview
In one paragraph

Review in The Lancet. Infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. UnveilingiScience · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Risk factors associated with IgG seropersistence toEpidemiology and infection · 2025
    Article
  14. Article
  15. Review
  16. The Emergence Potential ofArchives of Razi Institute · 2024
    Review
  17. Article
  18. Trends inSexually transmitted infections · 2024
    Article
  19. The serodiagnositic value ofFrontiers in public health · 2024
    Article
  20. Autophagy: the misty lands ofFrontiers in cellular and infection microbiology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 11 institutions in 6 countries.

Sarah C WoodhallBlood Safety, Hepatitis, Sexually Transmitted Infections (STI) and HIV Service, Public Health England, London, UK; National Institute for Health Research Health Protection Research Unit in Evaluation of Interventions, University of Bristol, Bristol, UK; National Institute for Health Research Health Protection Research Unit in Blood Borne and Sexually Transmitted Infections, University College London, London, UK. Electronic address: s.woodhall@nhs.net.
Rachel J GorwitzDivision of STD Prevention, US Centers for Disease Control and Prevention, Atlanta, GA, USA.
Stephanie J MigchelsenBlood Safety, Hepatitis, Sexually Transmitted Infections (STI) and HIV Service, Public Health England, London, UK; Clinical Research Department, London School of Hygiene & Tropical Medicine, London, UK.
Sami L GottliebDepartment of Reproductive Health and Research, World Health Organization, Geneva, Switzerland.
Patrick J HornerNational Institute for Health Research Health Protection Research Unit in Evaluation of Interventions, University of Bristol, Bristol, UK; Population Health Sciences, University of Bristol, Bristol, UK.
William M GeislerDivision of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL, USA.
Catherine WinstanleyFaculty of Medicine, University of Southampton, Southampton, UK.
Katrin HufnagelDivision of Molecular Diagnostics of Oncogenic Infections, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Tim WaterboerDivision of Molecular Diagnostics of Oncogenic Infections, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Diana L MartinDivision of Parasitic Diseases and Malaria, US Centers for Disease Control and Prevention, Atlanta, GA, USA.
Wilhelmina M HustonSchool of Life Sciences, University of Technology Sydney, Sydney, NSW, Australia.
Charlotte A GaydosDivision of Infectious Diseases, Johns Hopkins University, Baltimore, MD, USA.
Carolyn DealDivision of Microbiology and Infectious Diseases, National Institute of Health, Bethesda, MD, USA.
Magnus UnemoWHO Collaborating Centre for Gonorrhoea and Other Sexually Transmitted Infections, Örebro University, Örebro, Sweden.
J Kevin DunbarBlood Safety, Hepatitis, Sexually Transmitted Infections (STI) and HIV Service, Public Health England, London, UK; National Institute for Health Research Health Protection Research Unit in Evaluation of Interventions, University of Bristol, Bristol, UK; National Institute for Health Research Health Protection Research Unit in Blood Borne and Sexually Transmitted Infections, University College London, London, UK.
Kyle BernsteinDivision of STD Prevention, US Centers for Disease Control and Prevention, Atlanta, GA, USA.
Centers for Disease Control and Prevention · USGerman Cancer Research Center · DEUniversity of Bristol · GBJohns Hopkins University · USLondon School of Hygiene & Tropical Medicine · GBÖrebro University · SEPublic Health England · GBUniversity of Alabama at Birmingham · USUniversity of Southampton · GBUniversity of Technology Sydney · AUWorld Health Organization · CH

Funding

TrainingU54EB007958 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Yukari C Manabe, Susan Anne Tuddenham · 2007 to 2026
$34.6M
Intramural CDC HHS CC999999NIBIB NIH HHS U54 EB007958
6 · The paper itself

Abstract

Genital Chlamydia trachomatis infection is the most commonly diagnosed sexually transmitted infection. Trachoma is caused by ocular infection with C trachomatis and is the leading infectious cause of blindness worldwide. New serological assays for C trachomatis could facilitate improved understanding of C trachomatis epidemiology and prevention. C trachomatis serology offers a means of investigating the incidence of chlamydia infection and might be developed as a biomarker of scarring sequelae, such as pelvic inflammatory disease. Therefore, serological assays have potential as epidemiological tools to quantify unmet need, inform service planning, evaluate interventions including screening and treatment, and to assess new vaccine candidates. However, questions about the performance characteristics and interpretation of C trachomatis serological assays remain, which must be addressed to advance development within this field. In this Personal View, we explore the available information about C trachomatis serology and propose several priority actions. These actions involve development of target product profiles to guide assay selection and assessment across multiple applications and populations, establishment of a serum bank to facilitate assay development and evaluation, and development of technical and statistical methods for assay evaluation and analysis of serological findings. The field of C trachomatis serology will benefit from collaboration across the public health community to align technological developments with their potential applications.

Indexed as

Chlamydia trachomatisData Interpretation, StatisticalHumansIncidenceLymphogranuloma VenereumSerologic TestsTrachoma

Identifiers

PMID29983342
PMCPMC6414067
OpenAlexW2848284079

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.