Evidence map›Paper›PMID 29983082›Full record

ArticleInternational journal of immunopathology and pharmacology

Orexin-A protects SH-SY5Y cells against H

Chun-Mei Wang, Chun-Qing Yang, Bao-Hua Cheng, Jing Chen, Bo Bai

Open access · goldAbstract read
In one paragraph

Article in International journal of immunopathology and pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Peptidergic Systems and Neuroblastoma.International journal of molecular sciences · 2025
    Review
  4. Protective Effect of Arzanol against HInternational journal of molecular sciences · 2024
    Article
  5. Article
  6. Article
  7. Cell Model of Depression: Reduction of Cell Stress with Mirtazapine.International journal of molecular sciences · 2022
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. International journal of molecular sciences · 2020
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Chun-Mei Wang1 Neurobiology Key Laboratory of Jining Medical University in Colleges of Shandong, Jining, P.R. China.
Chun-Qing Yang1 Neurobiology Key Laboratory of Jining Medical University in Colleges of Shandong, Jining, P.R. China.
Bao-Hua Cheng1 Neurobiology Key Laboratory of Jining Medical University in Colleges of Shandong, Jining, P.R. China.
Jing Chen1 Neurobiology Key Laboratory of Jining Medical University in Colleges of Shandong, Jining, P.R. China.
Bo Bai1 Neurobiology Key Laboratory of Jining Medical University in Colleges of Shandong, Jining, P.R. China.ORCID https://orcid.org/0000-0001-9988-8318
Jining Medical University · CNUniversity of Warwick · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Orexin-A elicits multiple potent effects on a variety of tumor cells via different signaling pathways. However, it is unknown whether it has a neuroprotective effect on SH-SY5Y human neuroblastoma cells. This study investigated the neuroprotective effect of Orexin-A against hydrogen peroxide (H

Indexed as

ApoptosisApoptosis Regulatory ProteinsCell Line, TumorCell SurvivalHumansHydrogen PeroxideMAP Kinase Signaling SystemNeuroprotective AgentsOrexinsOxidantsOxidative StressPhosphatidylinositol 3-KinasesApoptosis Regulatory ProteinsHydrogen PeroxideNeuroprotective AgentsOrexinsOxidantsPhosphatidylinositol 3-Kinasesneuroprotective effectOrexin-Aoxidative damagePI3K/MEK/ERK pathway

Identifiers

PMID29983082
PMCPMC6073832
OpenAlexW2832872610

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.