Evidence map›Paper›PMID 29983043›Full record

ArticleBiochemistry2018

Dissection, Optimization, and Structural Analysis of a Covalent Irreversible DDAH1 Inhibitor.

Gayle Burstein-Teitelbaum, Joyce A V Er, Arthur F Monzingo, Alfred Tuley, Walter Fast

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Gayle Burstein-TeitelbaumDivision of Chemical Biology & Medicinal Chemistry, College of Pharmacy , University of Texas , Austin , Texas 78712 , United States.
Joyce A V ErDivision of Chemical Biology & Medicinal Chemistry, College of Pharmacy , University of Texas , Austin , Texas 78712 , United States.
Arthur F MonzingoCenter for Biomedical Research Support , University of Texas , Austin , Texas 78712 , United States.
Alfred TuleyDivision of Chemical Biology & Medicinal Chemistry, College of Pharmacy , University of Texas , Austin , Texas 78712 , United States.
Walter FastDivision of Chemical Biology & Medicinal Chemistry, College of Pharmacy , University of Texas , Austin , Texas 78712 , United States.ORCID 0000-0001-7567-2213
The University of Texas at Austin · US

Funding

IRACDA Postdoctoral Program: Collaborative Opportunities for Research EducatorsK12GM102745 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI BRODBELT, JENNIFER S. · 2013 to 2017
$2.2M
Enzymology of DimethylargininaseR01GM069754 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI FAST, WALTER L · 2008 to 2012
$1.9M
Howard Hughes Medical InstituteNIGMS NIH HHS K12 GM102745NIGMS NIH HHS R01 GM069754
6 · The paper itself

Abstract

Inhibitors of the human enzyme dimethylarginine dimethylaminohydrolase-1 (DDAH1) can control endogenous nitric oxide production. A time-dependent covalent inactivator of DDAH1, N

Indexed as

AmidinesAmidohydrolasesCrystallography, X-RayEnzyme InhibitorsHEK293 CellsHumansModels, MolecularNitric OxideOrnithineStructure-Activity RelationshipValine2-chloroacetamidineAmidinesAmidohydrolasesdimethylargininaseEnzyme InhibitorsN(5)-(1-imino-2-chloroethyl)ornithineNitric OxidenorvalineOrnithineValine

Identifiers

PMID29983043
PMCPMC6074031
OpenAlexW2881987215

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.