ArticlePlanta2018
Inhibition of α-ketoglutarate dehydrogenase activity affects adventitious root growth in poplar via changes in GABA shunt.
Article in Planta, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 40 citations in OpenAlex.
- TaGAD2 is a potential downstream effector of Rht5 in controlling wheat plant height.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Effect of Nitric Oxide on Adventitious Root Development from Cuttings of Sweetpotato and Associated Biochemical Changes.Plants (Basel, Switzerland) · 2025Article
- The Role of Glutamate Metabolism and the GABA Shunt in Bypassing the Tricarboxylic Acid Cycle in the Light.International journal of molecular sciences · 2024Article
- Relationship between the GABA Pathway and Signaling of Other Regulatory Molecules.International journal of molecular sciences · 2024Review
- Metabolomics reveal root differential metabolites of different root-type alfalfa under drought stress.Frontiers in plant science · 2024Article
- Interactions with microbial consortia have variable effects in organic carbon and production of exometabolites among genotypes ofPlant direct · 2023Article
- GABA Metabolism, Transport and Their Roles and Mechanisms in the Regulation of Abiotic Stress (Hypoxia, Salt, Drought) Resistance in Plants.Metabolites · 2023Review
- Integration of the metabolome and transcriptome reveals the molecular mechanism of drought tolerance inFrontiers in genetics · 2023Article
- Merging the occurrence possibility into gene co-expression network deciphers the importance of exogenous 2-oxoglutarate in improving the growth of rice seedlings under thiocyanate stress.Frontiers in plant science · 2023Article
- The Role of γ-Aminobutyric Acid (GABA) in the Occurrence of Adventitious Roots and Somatic Embryos in Woody Plants.Plants (Basel, Switzerland) · 2022Review
- Comprehensive Genome-Wide Identification and Transcript Profiling of GABA Pathway Gene Family in Apple (Genes · 2021Article
- The versatile GABA in plants.Plant signaling & behavior · 2021Review
- Mutual Promotion ofFrontiers in plant science · 2021Article
- Effects of GABA and Vigabatrin on the Germination of Chinese Chestnut Recalcitrant Seeds and Its Implications for Seed Dormancy and Storage.Plants (Basel, Switzerland) · 2020Article
- γ-Aminobutyric acid is closely associated with accumulation of flavonoids.Plant signaling & behavior · 2019Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
MAIN
conclusionBlocking α-ketoglutarate dehydrogenase results in up-regulation of γ-aminobutyric acid (GABA) shunt activity, and inhibits the growth of poplar adventitious roots (ARs), indicating that AR growth is closely associated with GABA shunt. γ-Aminobutyric acid (GABA) shunt starts from α-ketoglutarate in the tricarboxylic acid cycle, which is thought to represent the cross road between carbon and nitrogen metabolism. Previous studies (Araújo et al. 2012b, Plant Cell 24: 2328-2351) have shown that blocking α-ketoglutarate dehydrogenase (α-KGDH) affects the GABA shunt activity, and inhibits growth. However, its effects on the growth of adventitious roots (ARs) are unclear. In this study, the growth of ARs in tissue-cultured 84K poplar (Populus alba × Populus glandulosa cv. '84K') was significantly inhibited when succinyl phosphate (SP), a specific inhibitor of α-KGDH, was supplied. The inhibition of ARs was associated with significant changes in the levels of soluble sugars, organic acids, and amino acids, and was coupled with the up-regulation of the GABA shunt activity at the transcriptional and translational levels. Exogenous GABA also inhibited AR growth following the increase of the endogenous GABA level. Transcriptomic analyses further showed that genes related to cell wall carbon metabolism and phytohormone (indoleacetic acid, ABA, and ethylene) signaling were affected by the changes of GABA shunt activity, resulting from the α-KGDH inhibition. Thus, our study indicates that the inhibition of poplar AR growth by blocking α-KGDH is closely associated with GABA shunt, which would benefit a better understanding of GABA's roles in plant development and stress response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.