Evidence map›Paper›PMID 29982847›Full record

ReviewCellular and molecular life sciences : CMLS2018

Voltage-gated sodium currents in cerebellar Purkinje neurons: functional and molecular diversity.

Joseph L Ransdell, Jeanne M Nerbonne

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. A Reinterpretation of the Relationship between Persistent and Resurgent Sodium Currents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Joseph L RansdellDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO, 63110, USA.ORCID http://orcid.org/0000-0001-5908-9044
Jeanne M NerbonneDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO, 63110, USA. jnerbonne@wustl.edu.
Washington University in St. Louis · US

Funding

FGF14 IN THE REGULATION OF PURKINJE NEURON EXCITABILITY AND SCA27R01NS065761 · NINDS · WASHINGTON UNIVERSITY · PI NERBONNE, JEANNE M., ORNITZ, DAVID M · 2009 to 2013
$1.9M
iFGF14 Regulation of Cerebellar Neuron ExcitabilityF32NS090765 · NINDS · WASHINGTON UNIVERSITY · PI RANSDELL, JOSEPH L. · 2014 to 2017
$167k
Foundation for the National Institutes of Health F32NS090765Foundation for the National Institutes of Health R01NS065761NINDS NIH HHS F32 NS090765NINDS NIH HHS R01 NS065761
6 · The paper itself

Abstract

Purkinje neurons, the sole output of the cerebellar cortex, deliver GABA-mediated inhibition to the deep cerebellar nuclei. To subserve this critical function, Purkinje neurons fire repetitively, and at high frequencies, features that have been linked to the unique properties of the voltage-gated sodium (Nav) channels expressed. In addition to the rapidly activating and inactivating, or transient, component of the Nav current (I

Indexed as

Action PotentialsAnimalsCerebellumHumansIon Channel GatingNeuronsPurkinje CellsVoltage-Gated Sodium ChannelsVoltage-Gated Sodium ChannelsAccessory subunitCerebellumConductanceIntrinsic excitability

Identifiers

PMID29982847
PMCPMC6123253
OpenAlexW2858400727

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.