ArticleNucleic acids research2018
Coupled catabolism and anabolism in autocatalytic RNA sets.
Article in Nucleic acids research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Carbon Nanotube-Based Multi-Functional "Yin"-"Yang" Film: Dual Applications in Solar Water Evaporation and Blue Energy Harvesting.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Building Molecules by a Self-Replicator That Catalyzes Acyl Hydrazone Formation.Angewandte Chemie (International ed. in English) · 2026Article
- Metabolism-inspired chemical reaction networks for chemically driven dissipative oligoesterification.Angewandte Chemie (International ed. in English) · 2025Article
- Competitive exclusion among self-replicating molecules curtails the tendency of chemistry to diversify.Nature chemistry · 2025Article
- Light-driven eco-evolutionary dynamics in a synthetic replicator system.Nature chemistry · 2024Article
- Origin & influence of autocatalytic reaction networks at the advent of the RNA world.RNA biology · 2024Review
- The protometabolic nature of prebiotic chemistry.Chemical Society reviews · 2023Review
- Multispecies autocatalytic RNA reaction networks in coacervates.Communications chemistry · 2023Article
- Novel Apparatuses for Incorporating Natural Selection Processes into Origins-of-Life Experiments to Produce Adaptively Evolving Chemical Ecosystems.Life (Basel, Switzerland) · 2022Article
- Collective adaptability in a replication network of minimal nucleobase sequences.Chemical science · 2022Article
- An Approach to the De Novo Synthesis of Life.Accounts of chemical research · 2022Article
- Genome Evolution from Random Ligation of RNAs of Autocatalytic Sets.International journal of molecular sciences · 2021Article
- Natural Selection beyond Life? A Workshop Report.Life (Basel, Switzerland) · 2021Article
- Equilibrium and non-equilibrium furanose selection in the ribose isomerisation network.Nature communications · 2021Article
- Self-Reproduction and Darwinian Evolution in Autocatalytic Chemical Reaction Systems.Life (Basel, Switzerland) · 2021Review
- Darwinian properties and their trade-offs in autocatalytic RNA reaction networks.Nature communications · 2021Article
- On the definition of a self-sustaining chemical reaction system and its role in heredity.Biology direct · 2020Article
- From self-replication to replicator systems en route to de novo life.Nature reviews. Chemistry · 2020Review
- Emergence of light-driven protometabolism on recruitment of a photocatalytic cofactor by a self-replicator.Nature chemistry · 2020Article
- Predicting collapse of adaptive networked systems without knowing the network.Scientific reports · 2020Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability to process molecules available in the environment into useable building blocks characterizes catabolism in contemporary cells and was probably critical for the initiation of life. Here we show that a catabolic process in collectively autocatalytic sets of RNAs allows diversified substrates to be assimilated. We modify fragments of the Azoarcus group I intron and find that the system is able to restore the original native fragments by a multi-step reaction pathway. This allows in turn the formation of catalysts by an anabolic process, eventually leading to the accumulation of ribozymes. These results demonstrate that rudimentary self-reproducing RNA systems based on recombination possess an inherent capacity to assimilate an expanded repertoire of chemical resources and suggest that coupled catabolism and anabolism could have arisen at a very early stage in primordial living systems.
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