ArticleJournal of experimental botany2018
Members of the Arabidopsis FORKED1-LIKE gene family act to localize PIN1 in developing veins.
Article in Journal of experimental botany, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- PUCHI delimits the spatial domain of nodule organogenesis associated with auxin patterning and NIN-dependent transcription in Lotus japonicus.Journal of plant research · 2026Article
- Origin and diversity of leaf vein patterns.Journal of experimental botany · 2026Review
- FL7 is an ancient ABA-independent inhibitor of PP2C-As regulating plant stress responses.Nature communications · 2025Article
- Small, but mitey: investigating the molecular genetic basis for mite domatia development and intraspecific variation in Vitis riparia using transcriptomics.The New phytologist · 2025Article
- Single-cell network analysis reveals gene expression programs for Arabidopsis root development and metabolism.Plant communications · 2024Article
- Uncovering gene-family founder events during major evolutionary transitions in animals, plants and fungi using GenEra.Genome biology · 2023Article
- Genome-Wide Investigation and Co-Expression Network Analysis of SBT Family Gene inInternational journal of molecular sciences · 2023Article
- Functional Mapping of Genes Modulating Plant Shade Avoidance Using Leaf Traits.Plants (Basel, Switzerland) · 2023Article
- Article
- Connected function of PRAF/RLD and GNOM in membrane trafficking controls intrinsic cell polarity in plants.Nature communications · 2022Article
- Subcellular trafficking and post-translational modification regulate PIN polarity in plants.Frontiers in plant science · 2022Review
- Of Cells, Strands, and Networks: Auxin and the Patterned Formation of the Vascular System.Cold Spring Harbor perspectives in biology · 2021Review
- Article
- An abscisic acid-responsive protein interaction network for sucrose non-fermenting related kinase1 in abiotic stress response.Communications biology · 2020Article
- The PIN-FORMED Auxin Efflux Carriers in Plants.International journal of molecular sciences · 2018Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The reticulate leaf vein pattern typical of angiosperms is proposed to have been a driving force for their evolutionary success. Vein pattern is established through auxin canalization via the auxin efflux protein PINFORMED1 (PIN1). During formation of vein loops, PIN1 cellular localization is increasingly restricted to either the basal side of cells in the lower domain or to the apical side in the upper domain. We previously identified the gene FORKED1 (FKD1) to be required for PIN1 asymmetric localization and for the formation of closed vein loops. FKD1 encodes a plant-specific protein with a domain of unknown function (DUF828) and a Pleckstrin-like homology domain. The Arabidopsis genome encodes eight similar proteins, which we term the FORKED1-LIKE (FL) gene family. Five FL family members localize primarily to the trans-Golgi network or the Golgi, and several co-localize with FKD1-green flourescent protein (GFP) and RABA1c, suggesting action in the secretory pathway. While single FL gene family mutations do not result in vein pattern defects, triple mutants with mutations in FKD1, FL2, and FL3 result in a more symmetric PIN1 localization and a highly disconnected vein pattern. Our data suggest that FL genes act redundantly with FKD1 in the secretory pathway to establish appropriate PIN1 localization in provascular tissue.
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