ArticleSleep2018
Key insomnia symptoms and incident pain in older adults: direct and mediated pathways through depression and anxiety.
Article in Sleep, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Non-pharmacological interventions for improving sleep quality in adults aged 50 years and older: a systematic review and network meta-analysis.Archives of public health = Archives belges de sante publique · 2026Pooled it
- Longitudinal associations of pain and cognitive decline in community-dwelling older adults.Psychology and aging · 2022Trial
- Sleep quality differences among caregivers for persons living with and without dementia.Aging & mental health · 2024Article
- Pain-Insomnia-Depression Syndrome: Triangular Relationships, Pathobiological Correlations, Current Treatment Modalities, and Future Direction.Pain and therapy · 2024Review
- A nationwide study on pain manifestations and sleep problems in community-dwelling older adults: findings from ELSI-Brazil.European geriatric medicine · 2023Article
- Sleep staging in the ICU with heart rate variability and breathing signals. An exploratory cross-sectional study using deep neural networks.Frontiers in network physiology · 2023Article
- Longitudinal associations between time-varying insomnia symptoms and all-cause health care services utilization among middle-aged and older adults in the United States.Health services research · 2022Article
- The Affective Dimension of Pain Appears to Be Determinant within a Pain-Insomnia-Anxiety Pathological Loop in Fibromyalgia: A Case-Control Study.Journal of clinical medicine · 2022Article
- Alleviating Excessive Worries Improves Co-Occurring Depression and Pain in Adolescent and Young Adult Cancer Patients: A Network Approach.Neuropsychiatric disease and treatment · 2022Article
- Associates of Insomnia in People with Chronic Spinal Pain: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2021Review
- Associations between symptoms of pain, insomnia and depression, and frailty in older adults: A cross-sectional analysis of a cohort study.International journal of nursing studies · 2021Article
- The influence of sleep disturbances and sleep disorders on pain outcomes among veterans: A systematic scoping review.Sleep medicine reviews · 2021Article
- Psychosocial Factors Associated with Sleep Quality and Duration Among Older Adults with Chronic Pain.Population health management · 2021Article
- Differences in the Association of Anxiety, Insomnia and Somatic Symptoms between Medical Staff and the General Population During the Outbreak of COVID-19.Neuropsychiatric disease and treatment · 2021Article
- Independent and synergistic effects of pain, insomnia, and depression on falls among older adults: a longitudinal study.BMC geriatrics · 2020Article
- Health-related quality of life in hospitalized older patients with versus without prolonged use of opioid analgesics, benzodiazepines, and z-hypnotics: a cross-sectional study.BMC geriatrics · 2020Article
- Article
- Sleep and pain: recent insights, mechanisms, and future directions in the investigation of this relationship.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- Cannabinoid use among Americans with MS: Current trends and gaps in knowledge.Multiple sclerosis journal - experimental, translational and clinicalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Pain is common among older adults and negatively impacts functioning. Sleep disturbances and mood disorders, specifically depression and anxiety, are closely associated with pain in older individuals, but the directionality of these associations remains unclear. In this study, we deconstruct long-term temporal effects of two key insomnia symptoms on incident pain into direct and indirect pathways, with focus on depression and anxiety symptoms, within a nationally representative sample. We utilized 2011-2013 data from the National Health and Aging Trends Study, a longitudinal survey of 2239 community-dwelling Medicare beneficiaries. Participants completed annual in-person interviews with assessments of sleep initiation and maintenance; depression, and anxiety (using the Patient Health Questionnaire-2 [PHQ-2] and the Generalized Anxiety Disorder Scale-2 [GAD-2] respectively); and bothersome pain. Causal mediation analysis was applied to examine direct effects of the two insomnia symptoms at baseline on incident pain, and their indirect effects through depression and anxiety symptoms. Almost one-third of the study participants were 69 years old or younger. A similar proportion reported bothersome pain in 2013. The two baseline insomnia symptoms predicted the development of pain. Adjusted analyses suggested that compared to older adults without the two baseline insomnia symptoms, participants with sleep initiation or maintenance difficulties had 24% (95% confidence interval [CI] 2%,51%) and 28% (95% CI 4%,55%) higher odds of incident pain, respectively. Anxiety symptoms partially mediated the relationship between the insomnia symptoms and incident pain, accounting for up to 17% of the total effect, but depressive symptoms did not. These results suggest that improved sleep or anxiety could reduce the risk for future pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.