SynthesisSchizophrenia bulletin2019
Dysconnectivity of Large-Scale Functional Networks in Early Psychosis: A Meta-analysis.
Synthesis in Schizophrenia bulletin, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 4 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
76 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Adverse childhood experiences and resting state functional connectivity of the triple brain network: a meta-analysis.European archives of psychiatry and clinical neuroscience · 2026Pooled it
- Integrating Clinical Neuropsychology and Psychotic Spectrum Disorders: A Systematic Analysis of Cognitive Dynamics, Interventions, and Underlying Mechanisms.Medicina (Kaunas, Lithuania) · 2024Pooled it
- Spontaneous Brain Activity Alterations in First-Episode Psychosis: A Meta-analysis of Functional Magnetic Resonance Imaging Studies.Schizophrenia bulletin · 2023Pooled it
- Large-scale network dysfunction in the acute state compared to the remitted state of bipolar disorder: A meta-analysis of resting-state functional connectivity.EBioMedicine · 2020Pooled it
- Connectome dysfunction in patients at clinical high risk for psychosis and modulation by oxytocin.Molecular psychiatry · 2024Trial
- Higher-order functional brain networks and anterior cingulate glutamate + glutamine (Glx) in antipsychotic-naïve first episode psychosis patients.Translational psychiatry · 2024Trial
- Effects of Exercise on Structural and Functional Brain Patterns in Schizophrenia-Data From a Multicenter Randomized-Controlled Study.Schizophrenia bulletin · 2024Trial
- Cannabidiol attenuates insular dysfunction during motivational salience processing in subjects at clinical high risk for psychosis.Translational psychiatry · 2019Trial
- Mapping the psychosis spectrum - imaging neurosubtypes from multiscale functional network connectivity.Molecular psychiatry · 2026Article
- Temporal stability of functional network configurations and its relationship to cognition and psychopathology in early psychoses.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Disrupted hierarchical functional brain organization in affective and psychotic disorders: insights from functional brain gradients.Translational psychiatry · 2026Article
- The Salience of Psychotic Experiences: Neural Correlates in the General Population.Schizophrenia bulletin · 2026Article
- Network functional connectivity and anterior cingulate cortex gamma-aminobutyric acid in antipsychotic medication-naïve first-episode psychosis patients.Psychological medicine · 2026Article
- Cognitive subtypes and brain network differences in antipsychotic-naïve first-episode psychosis.Schizophrenia (Heidelberg, Germany) · 2026Article
- Negative symptoms and resting state functional connectivity: Leveraging ecological momentary assessment and individual-specific techniques.Schizophrenia research · 2026Article
- Whole brain grey matter synaptic terminal density, age and intellectual functioning in schizophrenia: an in vivo [Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- The association among glutamate, GABA, and anterior cingulate connectivity in schizophrenia spectrum disorders: Implications for symptom domains.European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- Associations between negative symptoms and resting-state functional connectivity within social brain networks among individuals with early psychosis.Schizophrenia (Heidelberg, Germany) · 2026Article
- Beyond severity: Mapping cognitive heterogeneity in schizophrenia at the structural level.medRxiv : the preprint server for health sciences · 2026Article
- Triple-Network Functional Connectivity in Adolescents With Autism Spectrum Disorder Compared to Early-Onset Psychosis.Autism research : official journal of the International Society for Autism Research · 2026Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
objectiveIncreasingly, studies have identified abnormalities in the functional connectivity (FC) of large-scale neural networks in early psychosis, but the findings thus far have been inconclusive. Therefore, the aim of this study was to identify robust alterations in FC of the default mode (DMN), salience (SN), and central executive networks (CEN), in patients with first-episode psychosis (FEP) using a meta-analytic approach.
methodsIncluded studies were required to be resting-state, seed-to-whole brain, FC neuroimaging studies, comparing FEP patients to healthy controls (HC), with seeds within the boundaries of the region-of-interest networks. Peak effect coordinates and peak t, z, or p values were meta-analyzed using Seed-based d Mapping software.
resultsThe DMN seeds primarily displayed within-network hypoconnectivity (largest clusters including the middle orbital gyrus; and ventral anterior cingulate gyrus). The SN seeds displayed hypoconnectivity with regions in the DMN and CEN (largest clusters located in the bilateral middle temporal gyri). Review of the limited CEN data revealed hypo- and hyperconnectivity across the networks. Negative symptoms were positively correlated with all DMN FC abnormalities in the FEP group. Antipsychotic-treated patients displayed greater hypoconnectivity than antipsychotic-naïve patients between both the DMN/SN seeds and prefrontal regions.
conclusionsThese findings provide substantial evidence of widespread resting-state FC abnormalities of the DMN, SN, and CEN in early psychosis; particularly implicating DMN and SN dysconnectivity as a core deficit underlying the psychopathology of psychosis. Additionally, we highlight the importance of disentangling connectivity abnormalities resulting from disease processes, from those that result from antipsychotic treatment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.