ArticleInternational journal of epidemiology2019
Are birthweight and postnatal weight gain in childhood associated with blood pressure in early adolescence? Results from a Ugandan birth cohort.
Article in International journal of epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Cohort profile: the Entebbe Mother and Baby Study (EMaBS).BMJ open · 2026Trial
- Effects of maternal calcium supplementation on offspring blood pressure and growth in childhood and adolescence in a population with a low-calcium intake: follow-up study of a randomized controlled trial.The American journal of clinical nutrition · 2024Trial
- Birthweight and cardiometabolic risk factors in offspring: A systematic review and meta-analysis of cohort studies.Archives of public health = Archives belges de sante publique · 2026Article
- Article
- From Insult to Injury: Exploring the Associations Between Severe Malnutrition in Childhood, Rehabilitation Weight Gain and Adult Adiposity in a Prospective Cohort Study.Maternal & child nutrition · 2026Article
- Determinants of overweight and obesity and other cardiometabolic risks in adolescents: a Spanish longitudinal birth study.Pediatric research · 2025Article
- Risks and Benefits of Weight Gain in Children With Undernutrition.JAMA network open · 2025Article
- The Impact of Rapid Growth After Retardation at the First 1000 Days of Life (FDLs) on the Risk of Noncommunicable Diseases in Indonesian Adolescence.International journal of pediatrics · 2025Article
- The contextual awareness, response and evaluation (CARE) diabetes project: study design for a quantitative survey of diabetes prevalence and non-communicable disease risk in Ga Mashie, Accra, Ghana.Global health action · 2024Article
- The association of gestational age and birthweight with blood pressure, cardiac structure, and function in 4 years old: a prospective birth cohort study.BMC medicine · 2023Article
- Weight status change from birth to childhood and the odds of high blood pressure among Chinese children.Frontiers in public health · 2023Article
- Hypertension among adolescents in sub-Saharan Africa: a systematic review.Frontiers in cardiovascular medicine · 2023Review
- Paediatric Hypertension in Africa: A Systematic Review and Meta-Analysis.EClinicalMedicine · 2022Article
- The determinants of lipid profiles in early adolescence in a Ugandan birth cohort.Scientific reports · 2021Article
- Current obesity was associated with hypertension in children born very low birth weight.BMC research notes · 2021Article
- Growth monitoring and mortality risk in low birthweight infants: a birth cohort study in Burkina Faso.Gates open research · 2021Article
- Early Determinants of Childhood Blood Pressure at the Age of 6 Years: The GECKO Drenthe and ABCD Study Birth Cohorts.Journal of the American Heart Association · 2020Article
- A genome-wide association and replication study of blood pressure in Ugandan early adolescents.Molecular genetics & genomic medicine · 2019Article
- Blood pressure risk factors in early adolescents: results from a Ugandan birth cohort.Journal of human hypertension · 2019Observational
- The effect of childhood stunting and wasting on adolescent cardiovascular diseases risk and educational achievement in rural Uganda: a retrospective cohort study.Global health action · 2019Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundIn Africa, where low birthweight (LBW), malnutrition and high blood pressure (BP) are prevalent, the relationships between birthweight (BW), weight gain and BP later in life remain uncertain. We examined the effects of early life growth on BP among Ugandan adolescents.
methodsData were collected prenatally from women and their offspring were followed from birth, with BP measured following standard protocols in early adolescence. Weight-for-age Z-scores (WAZ) were computed using World Health Organization references. Linear regression was used to relate BW, and changes in WAZ between birth and 5 years, to adolescents' BP, adjusting for confounders.
resultsAmong 2345 live offspring, BP was measured in 1119 (47.7%) adolescents, with mean systolic BP 105.9 mmHg and mean diastolic BP 65.2 mmHg. There was little evidence of association between BW and systolic [regression coefficient β = 0.14, 95% confidence interval (CI) (-1.00, 1.27)] or diastolic [β = 0.43, 95% CI (-0.57, 1.43)] BP. Accelerated weight gain between birth and 5 years was associated with increased BP: systolic β = 1.17, 95% CI (0.69, 1.66) and diastolic β = 1.03, 95% CI (0.59, 1.47). Between birth and 6 months of age, effects of accelerated weight gain on adolescent BP were strongest among the LBW (both premature and small-for-gestational-age) children [BW < 2.5 kg: β = 2.64, 95% CI (0.91, 4.37), BW≥2.5 kg: β = 0.58, 95% CI (0.01, 1.14), interaction P-value = 0.024].
conclusionsFindings from this large tropical birth cohort in Uganda suggest that postnatal weight gain rather than BW is important in the developmental programming of BP, with fast-growing LBW children at particular risk. Efforts to control BP should adopt a life course approach.
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