Evidence map›Paper›PMID 29982608›Full record

Trial reportNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2019

Angiotensin-related genetic determinants of cardiovascular disease in patients undergoing hemodialysis.

Sharon M Moe, Jin Long, Tae-Hwi Linus Schwantes-An, Brian S Decker, Leah Wetherill, Howard J Edenberg, Xiaoling Xuei, Matteo Vatta, Tatiana M Foroud, Glenn M Chertow

Open access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Sharon M MoeDivision of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Jin LongDivision of Nephrology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Tae-Hwi Linus Schwantes-AnDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Brian S DeckerDivision of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Leah WetherillDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Howard J EdenbergDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Xiaoling XueiDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Matteo VattaDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Tatiana M ForoudDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Glenn M ChertowDivision of Nephrology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Indiana University – Purdue University Indianapolis · USIndiana University School of MedicineRichard L. Roudebush VA Medical Center · USStanford Medicine · USStanford University · US

Funding

Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Genetic risks for cardiovascular events in ESRD patients from the EVOLVE study.R01DK100306 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M · 2014 to 2016
$1.0M
NCATS NIH HHS UL1 TR002529NIDDK NIH HHS R01 DK100306
6 · The paper itself

Abstract

backgroundCardiovascular mortality in patients receiving dialysis remains unacceptably high, with unexplained ancestry differences suggesting a genetic component.

methodsWe analyzed DNA samples from 37% of subjects enrolled in the EValuation Of Cinacalcet Hydrochloride (HCl) Therapy to Lower CardioVascular Events (EVOLVE) trial, a randomized trial conducted in patients receiving hemodialysis with secondary hyperparathyroidism, comparing cinacalcet to placebo on a background of usual care. DNA was analyzed for single-nucleotide polymorphisms (SNPs) in the genes encoding the angiotensin-converting enzyme receptor type I (AGTR1) and angiotensin-converting enzyme (ACE). Survival analyses were conducted separately in European Ancestry (EA) and African Ancestry (AfAn) due to known differences in cardiovascular events, minor alleles for the same variant and the frequency of minor alleles. Our primary determination was a meta-analysis across both races.

resultsMeta-analysis showed significant associations between rs5186 in AGTR1 and increased rates by 25-34% for the primary endpoint (composite of death or nonfatal myocardial infarction, hospitalization for unstable angina, heart failure or peripheral vascular event), all-cause mortality, cardiovascular mortality and heart failure; all P < 0.001. Three correlated SNPs in ACE were associated with lower rates of sudden cardiac death (SCD) in EA samples. One ACE SNP, rs4318, only found in the AfAn samples, was associated with a lower rate of SCD in the AfAn samples.

conclusionsThe C allele in rs5186 in AGTR1 was associated with higher rates of death and major cardiovascular events in a meta-analysis of EA and AfAn patients with end-stage kidney disease. SNPs in ACE were associated with SCD.

Indexed as

Polymorphism, Single NucleotideAngiotensinsCardiovascular DiseasesCinacalcetFemaleHumansHyperparathyroidism, SecondaryKidney Failure, ChronicMaleMeta-Analysis as TopicMiddle AgedPeptidyl-Dipeptidase APrognosisReceptor, Angiotensin, Type 1Renal DialysisSurvival RateACE protein, humanAGTR1 protein, humanAngiotensinsCinacalcetPeptidyl-Dipeptidase AReceptor, Angiotensin, Type 1angiotensincardiovascular mortalitygeneticshemodialysisrenin–angiotensin–aldosterone system

Identifiers

PMID29982608
PMCPMC6826165
OpenAlexW2810491422

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.