ArticleBrain : a journal of neurology2018
Localizing parkinsonism based on focal brain lesions.
Article in Brain : a journal of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 7 of them syntheses that pooled it.
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Who cites it
98 citing papers in PubMed, 7 syntheses or guidelines pooled it, 156 citations in OpenAlex.
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- The role of the intraparietal sulcus in numeracy: A review of parietal lesion cases.Behavioural brain research · 2025Pooled it
- A neural network for tics: insights from causal brain lesions and deep brain stimulation.Brain : a journal of neurology · 2022Pooled it
- Clinical and Structural Findings in Patients With Lesion-Induced Dystonia: Descriptive and Quantitative Analysis of Published Cases.Neurology · 2022Pooled it
- A depression network caused by brain tumours.Brain structure & function · 2022Pooled it
- Neural substrates of motivational dysfunction across neuropsychiatric conditions: Evidence from meta-analysis and lesion network mapping.Clinical psychology review · 2022Pooled it
- Mapping holmes tremor circuit using the human brain connectome.Annals of neurology · 2019Pooled it
- A randomised, double-blind, sham-controlled trial of deep brain stimulation of the bed nucleus of the stria terminalis for treatment-resistant obsessive-compulsive disorder.Translational psychiatry · 2021Trial
- Mapping structural and functional brain networks associated with migraine.The journal of headache and pain · 2026Article
- Structural Connectome Alterations in Alternating Hemiplegia of Childhood.Brain topography · 2026Article
- Brain Structural and Functional Alteration Network Localization of Visual Hallucinations.Schizophrenia bulletin · 2026Article
- Converging metabolic and functional networks for tremor expression and deep brain stimulation-mediated control.NPJ Parkinson's disease · 2026Article
- Multimodal network localization of brain abnormalities and neuromodulation target identification in obsessive-compulsive disorder.Scientific reports · 2026Article
- Monoaminergic Networks of Cognitive and Behavioral Symptoms in Early Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Network Localization of Fatigue in Multiple Sclerosis.Annals of clinical and translational neurology · 2026Article
- Brain network localization of anhedonia.Translational psychiatry · 2026Article
- Specific Glutamatergic Projection to Claustrum for Regulating Methamphetamine Abstinence Anxiety-Like Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Mapping the Neuroanatomy of Dystonia Using Causal Brain Lesions.medRxiv : the preprint server for health sciences · 2025Article
- Cerebellar Dentate Cavernoma Enlargement and Tremor Emergence: Longitudinal Neuroimaging Analysis of Case Report and Literature Review.Movement disorders clinical practice · 2025Article
- Mapping Lesion-Related Human Aggression to a Common Brain Network.Biological psychiatry · 2025Article
38 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
Abstract
Bradykinesia, rigidity, and tremor frequently co-occur, a clinical syndrome known as parkinsonism. Because this syndrome is commonly seen in Parkinson's disease, symptoms are often attributed to cell loss in the substantia nigra. However, parkinsonism occurs in several other neurological disorders and often fails to correlate with nigrostriatal pathology, raising the question of which brain region(s) cause this syndrome. Here, we studied cases of new-onset parkinsonism following focal brain lesions. We identified 29 cases, only 31% of which hit the substantia nigra. Lesions were located in a variety of different cortical and subcortical locations. To determine whether these heterogeneous lesion locations were part of a common brain network, we leveraged the human brain connectome and a recently validated technique termed lesion network mapping. Lesion locations causing parkinsonism were functionally connected to a common network of regions including the midbrain, basal ganglia, cingulate cortex, and cerebellum. The most sensitive and specific connectivity was to the claustrum. This lesion connectivity pattern matched atrophy patterns seen in Parkinson's disease, progressive supranuclear palsy, and multiple system atrophy, suggesting a shared neuroanatomical substrate for parkinsonism. Lesion connectivity also predicted medication response and matched the pattern of effective deep brain stimulation, suggesting relevance as a treatment target. Our results, based on causal brain lesions, lend insight into the localization of parkinsonism, one of the most common syndromes in neurology. Because many patients with parkinsonism fail to respond to dopaminergic medication, these results may aid the development of alternative treatments.10.1093/brain/awy161_video1awy161media15815555971001.
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