ArticleBMJ open2018
Risk of pleural empyema in patients with schizophrenia: a nationwide propensity-matched cohort study in Taiwan.
Article in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 11 citations in OpenAlex.
- Empyema in a Patient with Schizophrenia Using Clozapine: A Case Report.Psychiatry and clinical psychopharmacology · 2022Article
- COVID-related hospitalization, intensive care treatment, and all-cause mortality in patients with psychosis and treated with clozapine.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2022Article
- Clozapine treatment and risk of COVID-19 infection: retrospective cohort study.The British journal of psychiatry : the journal of mental science · 2021Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThoracic infection and pneumonia are prevalent in patients with schizophrenia; however, it is unclear whether patients with schizophrenia are at an increased risk of developing pleural empyema.
designA retrospective cohort study with propensity-matched cohorts with and without schizophrenia.
settingUsing the National Health Insurance Research Database of Taiwan.
participantsWe identified 55 888 patients with schizophrenia newly diagnosed in 2000-2011 and same number of individuals without schizophrenia as the comparison cohort, frequency matched by propensity scores estimated using age, sex, occupation, income, urbanisation, year of diagnosis and comorbidities. PRIMARY OUTCOME MEASURES: We assessed incident pleural empyema by the end of 2011 and used the Cox proportional hazards model to calculate the schizophrenia cohort to comparison cohort HR of pleural empyema.
resultsThe overall incidence of pleural empyema was 2.44-fold greater in the schizophrenia cohort than in the comparison cohort (4.39vs1.80 per 10 000 person-years), with an adjusted HR of 2.87(95% CI 2.14 to 3.84). Stratified analyses by age, sex, occupation, income, urbanisation and comorbidity revealed significant hazards for pleural empyema associated with schizophrenia in all subgroups.
conclusionsPatients with schizophrenia are at an increased risk of developing pleural empyema and require greater attention and appropriate support.
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