ArticleTranslational oncology2018
Clinicopathologic Factors Related to the Histological Tumor Grade of Breast Cancer in Western China: An Epidemiological Multicenter Study of 8619 Female Patients.
Article in Translational oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Mathematical Pathological Approach as a Novel Tool for Prognosis in Breast Cancer.Indian journal of surgical oncology · 2025Article
- The use of mammography-based radiomics nomograms for the preoperative prediction of the histological grade of invasive ductal carcinoma.Journal of cancer research and clinical oncology · 2023Article
- Nomogram model combining macro and micro tumor-associated collagen signatures obtained from multiphoton images to predict the histologic grade in breast cancer.Biomedical optics express · 2021Article
- Germline mutations of multiple breast cancer-related genes are differentially associated with triple-negative breast cancers and prognostic factors.Journal of human genetics · 2020Article
- Clinical features and first degree relative breast cancer, their correlation with histological tumor grade: a 5-year retrospective case study of breast cancer in Mizoram, India.Environmental science and pollution research international · 2020Article
- Overexpression and mutation ofTranslational cancer research · 2019Article
- Noninvasive Assessment of Tumor Histological Grade in Invasive Breast Carcinoma Based on Ultrasound Radiomics and Clinical Characteristics: A Multicenter Study.Technology in cancer research & treatmentArticle
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Authors and funding
24 authors.
Funding
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Abstract
background and purposeBreast cancer is now recognized as a clinically heterogeneous disease with a wide spectrum of epidemiological and clinicopathologic features. We aimed to evaluate whether epidemiological and clinicopathologic features are associated with the histological tumor grade of breast carcinomas in Western China.
methodsWe retrospectively collected data from the Western China Clinical Cooperation Group and assessed associations between clinicopathologic factors and histological tumor grade in 8619 female breast cancer patients. Patients were divided into two groups: Group I (tumor grade I/II) and Group II (tumor grade III). Univariable analysis and multivariable logistic regression models were used to analyze the relationships between clinicopathologic factors and tumor grade.
resultsPatients presenting with positive axillary lymph nodes, large tumor size (>2 cm), lymphovascular invasion, hormone receptor negativity, human epidermal growth factor receptor 2 (HER-2) positivity, and triple negativity tended to have an increased risk of a high tumor grade. However, the number of pregnancies or births was inversely correlated with the risk of a high tumor grade. In addition, patients presenting with grade III tumors were more likely to receive aggressive treatment, such as adjuvant chemotherapy, anti-HER-2 therapy, and level III axillary lymph node dissection.
conclusionsOur results suggested that several clinicopathologic factors were associated with high tumor grade of breast cancer patients in Western China.
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