Evidence map›Paper›PMID 29981938›Full record

ArticleBehaviour research and therapy2018

Exploring the boundaries of post-retrieval extinction in healthy and anxious individuals.

M Alexandra Kredlow, Scott P Orr, Michael W Otto

Abstract read
In one paragraph

Article in Behaviour research and therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Reconsolidation and Fear Extinction: An Update.Current topics in behavioral neurosciences · 2023
    Article
  9. Article
  10. Article
  11. No persistent attenuation of fear memories in humans: A registered replication of the reactivation-extinction effect.Cortex; a journal devoted to the study of the nervous system and behavior · 2020
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

M Alexandra KredlowDepartment of Psychological & Brain Sciences, Boston University, 648 Beacon Street, 5th Floor, Boston, MA 02215, United States. Electronic address: kredlow@bu.edu.
Scott P OrrDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, East Building 120 -2nd Avenue, Charlestown, MA 02129, United States. Electronic address: scott_orr@hms.harvard.edu.
Michael W OttoDepartment of Psychological & Brain Sciences, Boston University, 648 Beacon Street, 5th Floor, Boston, MA 02215, United States. Electronic address: mwotto@bu.edu.

Funding

Exploring the Boundaries of Post-Retrieval Extinction in Anxious IndividualsF31MH103969 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI KREDLOW, MARIA ALEXANDRA G · 2014 to 2016
$104k
NIMH NIH HHS F31 MH103969
6 · The paper itself

Abstract

Over a dozen studies have examined the efficacy of post-retrieval extinction (PRE) in healthy adults in the fear conditioning laboratory, with a recent meta-analysis reporting an overall small-moderate effect on attenuating the return of fear compared to standard extinction. The current study was designed to extend PRE effects to a mixed sample of healthy and anxious individuals, explore potential moderators, and examine the benefit of PRE for a memory conditioned over multiple days. Healthy (n = 49) and anxious (n = 43) adults received either one day of acquisition followed by PRE, one day of acquisition followed by extinction, or three days of acquisition followed by PRE. Comparing participants who received one day of acquisition followed by PRE or extinction, no significant effect of PRE was observed on differential skin conductance response reinstatement or reactivity to the conditioned stimulus alone. Anxiety symptoms did not moderate outcomes. There was no difference in return of fear for anxious participants who received three days of acquisition followed by PRE versus one day of acquisition followed by PRE. These results further highlight the variability of findings in the PRE literature and need for further examination of individual difference factors that may moderate PRE effects.

Indexed as

AdolescentAdultAgedAnxietyCase-Control StudiesConditioning, ClassicalExtinction, PsychologicalFearFemaleGalvanic Skin ResponseHumansMaleMiddle AgedYoung AdultConditioningExtinctionFearPost-retrieval extinctionReconsolidationRetrieval extinction

Identifiers

PMID29981938
PMCPMC7437718

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.