Evidence map›Paper›PMID 29981811›Full record

ArticleCancer letters2018

Prolactin signaling drives tumorigenesis in human high grade serous ovarian cancer cells and in a spontaneous fallopian tube derived model.

Subbulakshmi Karthikeyan, Angela Russo, Matthew Dean, Daniel D Lantvit, Michael Endsley, Joanna E Burdette

Open access · greenAbstract read
In one paragraph

Article in Cancer letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Loss of phosphatase and tensin homolog (Cancer pathogenesis and therapy · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
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  11. Article
  12. Prolactin and Risk of Epithelial Ovarian Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021
    Article
  13. Review
  14. Article
  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Subbulakshmi KarthikeyanCenter for Biomolecular Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60607, USA.
Angela RussoCenter for Biomolecular Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60607, USA.
Matthew DeanCenter for Biomolecular Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60607, USA.
Daniel D LantvitCenter for Biomolecular Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60607, USA.
Michael EndsleyCenter for Biomolecular Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60607, USA; Medical College of Wisconsin, Department of Obstetrics & Gynecology, 9200 West Wisconsin Ave, Milwaukee, WI, 53226-3522, USA.
Joanna E BurdetteCenter for Biomolecular Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60607, USA. Electronic address: joannab@uic.edu.
University of Illinois Chicago · US

Funding

PCOS and androgen-related disease modeling and drug testing in Multi-organ Integrated Microfluidic Reproductive PlatformUG3ES029073 · NIEHS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WOODRUFF, TERESA K · 2017 to 2018
$3.0M
NIEHS NIH HHS UG3 ES029073
6 · The paper itself

Abstract

The pathways responsible for tumorigenesis of high grade serous ovarian cancer (HGSOC) from the fallopian tube epithelium (FTE) are still poorly understood. A human prolactin (PRL) like gene, Prl2c2 was amplified >100 fold in a spontaneous model of FTE-derived ovarian cancer (MOE

Indexed as

AnimalsCarcinogenesisCarcinoma, Ovarian EpithelialCell Line, TumorCell ProliferationCRISPR-Cas SystemsFallopian Tube NeoplasmsFemaleGene Expression Regulation, NeoplasticGene Knockout TechniquesHumansMiceMice, NudeOvarian NeoplasmsProlactinProto-Oncogene ProteinsPrl2c2 protein, mouseProlactinProto-Oncogene ProteinsReceptors, ProlactinWnt7b protein, mouseWnt ProteinsHigh grade serous ovarian cancer and p53 phosphorylationProlactinProlactin receptorSpontaneous fallopian tube derived ovarian cancer model

Identifiers

PMID29981811
PMCPMC6691889
OpenAlexW2864504266

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.