ArticleMicrobial cell factories2018
Rational modification of tricarboxylic acid cycle for improving L-lysine production in Corynebacterium glutamicum.
Article in Microbial cell factories, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 72 citations in OpenAlex.
- Photosynthetic production of glutamine through metabolic analysis-based engineering ofMetabolic engineering communications · 2026Article
- Performance comparison of downstream unit operations and process chains for the purification of amino acids for food, feed and pharma applications.Biotechnology reports (Amsterdam, Netherlands) · 2026Review
- EngineeringSynthetic and systems biotechnology · 2024Article
- Effect of TetR Family Transcriptional Regulator PccD on Phytosterol Metabolism ofMicroorganisms · 2024Article
- Novel Bioproduction of 1,6-Hexamethylenediamine from l-Lysine Based on an Artificial One-Carbon Elongation Cycle.ACS omega · 2024Article
- Enhanced ε-Poly-L-Lysine Production inBiomolecules · 2024Article
- Recent Advances in Metabolic Engineering for the Biosynthesis of Phosphoenol Pyruvate-Oxaloacetate-Pyruvate-Derived Amino Acids.Molecules (Basel, Switzerland) · 2024Review
- Oxaloacetate as new inducer for osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells in vitro.Molecular biology reports · 2024Article
- Rational reformation of Corynebacterium glutamicum for producing L-lysine by one-step fermentation from raw corn starch.Applied microbiology and biotechnology · 2022Article
- Construction of an ultra-strong PtacM promoter via engineering the core-element spacer and 5' untranslated region for versatile applications inBiotechnology notes (Amsterdam, Netherlands) · 2022Article
- Identification of key genes through the constructed CRISPR-dcas9 to facilitate the efficient production of O-acetylhomoserine inFrontiers in bioengineering and biotechnology · 2022Article
- Reconstruction of the Diaminopimelic Acid Pathway to Promote L-lysine Production inInternational journal of molecular sciences · 2021Article
- Transcriptome analysis reveals the roles of nitrogen metabolism and sedoheptulose bisphosphatase pathway in methanol-dependent growth of Corynebacterium glutamicum.Microbial biotechnology · 2021Article
- Biosensor-Based Multigene Pathway Optimization for Enhancing the Production of Glycolate.Applied and environmental microbiology · 2021Article
- The Development of Bacteriophage Resistance inViruses · 2021Article
- Droplet-Based Microfluidic High Throughput Screening ofFrontiers in bioengineering and biotechnology · 2021Article
- Pathway engineering ofMetabolic engineering communications · 2020Article
- Metabolic engineering of carbohydrate metabolism systems in Corynebacterium glutamicum for improving the efficiency of L-lysine production from mixed sugar.Microbial cell factories · 2020Article
- Improving phytosterol biotransformation at low nitrogen levels by enhancing the methylcitrate cycle with transcriptional regulators PrpR and GlnR of Mycobacterium neoaurum.Microbial cell factories · 2020Article
- Efficient bioproduction of 5-aminolevulinic acid, a promising biostimulant and nutrient, from renewable bioresources by engineeredBiotechnology for biofuels · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundOxaloacetate (OAA) and L-glutamate are essential precursors for the biosynthesis of L-lysine. Reasonable control of all potentially rate-limiting steps, including the precursors supply rate, is of vital importance to maximize the efficiency of L-lysine fermentation process.
resultsIn this paper, we have rationally engineered the tricarboxylic acid (TCA) cycle that increased the carbon yield (from 36.18 to 59.65%), final titer (from 14.47 ± 0.41 to 23.86 ± 2.16 g L
conclusionsOur results reveal that sufficient biomass, OAA and L-glutamate are equally important in the development of L-lysine high-yielding strain, and it is the first time to verify that fed-batch biotin plays a positive role in improving L-lysine production.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.