Evidence map›Paper›PMID 29981569›Full record

ArticleBMC pediatrics2018

The DIAMOND trial - DIfferent Approaches to MOderate & late preterm Nutrition: Determinants of feed tolerance, body composition and development: protocol of a randomised trial.

Frank H Bloomfield, Jane E Harding, Michael P Meyer, Jane M Alsweiler, Yannan Jiang, Clare R Wall, Tanith Alexander, DIAMOND Study Group

Abstract readClinical Trial Protocol
In one paragraph

Article in BMC pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Oral stimulation for promoting oral feeding in preterm infants.The Cochrane database of systematic reviews · 2023
    Review
  6. Article
  7. Glucocorticoids in preterm human milk.Frontiers in nutrition · 2022
    Article
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  16. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Frank H BloomfieldLiggins Institute, University of Auckland, Private Bag, Auckland, 92019, New Zealand. f.bloomfield@auckland.ac.nz.ORCID 0000-0001-6424-6577
Jane E HardingLiggins Institute, University of Auckland, Private Bag, Auckland, 92019, New Zealand.
Michael P MeyerThe Department of Paediatrics: Child and Youth Health, University of Auckland, Auckland, New Zealand.
Jane M AlsweilerNewborn Services, Auckland City Hospital, Auckland, New Zealand.
Yannan JiangDepartment of Statistics, Faculty of Science, University of Auckland, Auckland, New Zealand.
Clare R WallDepartment of Nutrition, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Tanith AlexanderLiggins Institute, University of Auckland, Private Bag, Auckland, 92019, New Zealand.
DIAMOND Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBabies born at moderate-late preterm gestations account for > 80% of all preterm births. Although survival is excellent, these babies are at increased risk of adverse neurodevelopmental outcomes. They also are at increased risk of adverse long-term health outcomes, such as cardiovascular disease, obesity and diabetes. There is little evidence guiding optimal nutritional practices in these babies; practice, therefore, varies widely. This factorial design clinical trial will address the role of parenteral nutrition, milk supplementation and exposure of the preterm infant to taste and smell with each feed on time to tolerance of full feeds, adiposity, and neurodevelopment at 2 years. METHODS/

designThe DIAMOND trial is a multi-centre, factorial, randomised, controlled clinical trial. A total of 528 babies born between 32 SECONDARY OUTCOMES: Days to full sucking feeds; days in hospital; body composition at discharge; growth to 2 years' corrected age; development at 2 years' corrected age; breastfeeding rates. DISCUSSION: This trial will provide the first direct evidence to inform feeding practices in moderate- to late-preterm infants that will optimise their growth, metabolic and developmental outcomes.

trial registrationAustralian New Zealand Clinical Trials Registry - ACTRN12616001199404 . This trial is endorsed by the IMPACT clinical trials network ( https://impact.psanz.com.au ).

Indexed as

Body CompositionBreast FeedingChild DevelopmentInfant FormulaInfant, PrematureParenteral NutritionSmellTasteHumansInfantInfant, NewbornMilk, HumanMulticenter Studies as TopicRandomized Controlled Trials as TopicBreastmilkEarly nutritionGrowthNeurodevelopmental outcomePretermRandomised factorial designTaste and smell

Identifiers

PMID29981569
PMCPMC6035796

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.