Evidence map›Paper›PMID 29981358›Full record

ArticleBrain research bulletin2018

Long-term effects of curcumin in the non-human primate brain.

Bang-Bon Koo, Samantha Calderazzo, Bethany G E Bowley, Alekha Kolli, Mark B Moss, Douglas L Rosene, Tara L Moore

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain research bulletin, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
  2. Review
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  4. Article
  5. Review
  6. Diet, psychosocial stress, and Alzheimer's disease-related neuroanatomy in female nonhuman primates.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021
    Article
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  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Bang-Bon KooDepartment of Anatomy and Neurobiology, School of Medicine, Boston University, Boston, MA, USA. Electronic address: bbkoo@bu.edu.
Samantha CalderazzoDepartment of Anatomy and Neurobiology, School of Medicine, Boston University, Boston, MA, USA.
Bethany G E BowleyDepartment of Anatomy and Neurobiology, School of Medicine, Boston University, Boston, MA, USA.
Alekha KolliBA/MD Program, Boston University, Boston, MA, USA.
Mark B MossDepartment of Anatomy and Neurobiology, School of Medicine, Boston University, Boston, MA, USA; BA/MD Program, Boston University, Boston, MA, USA; Department of Neurology, School of Medicine, Boston University, Boston, MA, USA.
Douglas L RoseneDepartment of Anatomy and Neurobiology, School of Medicine, Boston University, Boston, MA, USA; Department of Neurology, School of Medicine, Boston University, Boston, MA, USA.
Tara L MooreDepartment of Anatomy and Neurobiology, School of Medicine, Boston University, Boston, MA, USA; BA/MD Program, Boston University, Boston, MA, USA.
Boston University · US

Funding

Histopathology, Neuroimaging and Mechanism of Myelin Damage in Aging Monkey BrainR01AG043640 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROSENE, DOUGLAS L · 2013 to 2017
$3.0M
The effect of curcumin on age-related cognitive decline in the rhesus monkeyR01AG043478 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MOSS, MARK BARRY · 2013 to 2017
$2.9M
The efficacy of curcumin to facilitate recovery of function in a rhesus monkey model of cortical injury.R56AG059693 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MEDALLA, MARIA, MOORE, TARA L · 2018 to 2018
$792k
NIA NIH HHS R01 AG043478NIA NIH HHS R01 AG043640NIA NIH HHS R56 AG059693
6 · The paper itself

Abstract

Curcumin has recently been shown to be a potential treatment for slowing or ameloriating cognitive decline during aging in our nonhuman primate model of normal aging. In these same monkeys, we studied for the first time the neurological impacts of long-term curcumin treatments using longitudinal magnetic resonance imaging (MRI). Sixteen rhesus monkeys received curcumin or a vehicle control for 14-18 months. We applied a combination of structural and diffusion MRI to determine whether the curcumin resulted in structural or functional changes in focal regions of the brain. The longitudinal imaging revealed decreased microscale diffusivity (mD) measurements mainly in the hippocampus and basal forebrain structures of curcumin treated animals. Changes in generalized fractional anisotropy (GFA) and grey matter density (GMd) measurements indicated an increased grey matter density in cortical ROIs with improved white matter integrity in limbic, cerebellar, and brain stem regions. These findings suggest that noticeable changes in the neuronal environment could be induced from long-term curcumin treatments. Results may provide a neurological basis on the recent findings demonstrating improved spatial working memory and motor function in nonhuman primates.

Indexed as

AnimalsAnti-Inflammatory Agents, Non-SteroidalBrainCurcuminFemaleImage Processing, Computer-AssistedInflammationLongitudinal StudiesMacaca mulattaMagnetic Resonance ImagingMaleMemory, Short-TermMotor ActivityNootropic AgentsSpatial MemoryTime FactorsAnti-Inflammatory Agents, Non-SteroidalCurcuminNootropic AgentsAgingBrainCognitionCurcuminDiffusionLogitudinalMemoryMRIRestricted diffusionRhesus monkey

Identifiers

PMID29981358
PMCPMC6766340
OpenAlexW2810413738

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.