Evidence map›Paper›PMID 29980980›Full record

ArticleNeuromolecular medicine2018

Cerebrospinal Fluid C-Reactive Protein in Parkinson's Disease: Associations with Motor and Non-motor Symptoms.

Hossein Sanjari Moghaddam, Zahra Valitabar, Amir Ashraf-Ganjouei, Mahtab Mojtahed Zadeh, Farzaneh Ghazi Sherbaf, Mohammad Hadi Aarabi

Abstract read
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In one paragraph

Article in Neuromolecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.

  1. Pooled it
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  3. The brain and heart-axis in neurodegeneration and cardiovascular disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hossein Sanjari MoghaddamFaculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Zahra ValitabarFaculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Amir Ashraf-GanjoueiFaculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Mahtab Mojtahed ZadehFaculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Farzaneh Ghazi SherbafFaculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Hadi AarabiFaculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Mohammadhadiarabi@gmail.com.ORCID http://orcid.org/0000-0002-5550-9782
Tehran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson' disease (PD) is characterized by motor symptoms including bradykinesia, resting tremor, postural instability, and rigidity and non-motor symptoms such as cognitive impairment, sleep disorder, and depression. Neuroinflammation has been recently implicated in pathophysiology of both motor and non-motor symptoms of PD. One of the most notable inflammatory proteins is C-reactive protein (CRP), which is elevated in the conditions of systemic inflammation. Using BioFIND database, we scrutinized the possible association between cerebrospinal fluid (CSF) levels of CRP and severity of PD motor and non-motor symptoms. Eighty-four healthy controls (HCs) and 109 PD subjects were entered into this study. A significant correlation was observed between CSF CRP levels and Movement Disorder Society-Unified Parkinson's Disease Rating Scale Part III (MDS-UPDRS part III) score and Montreal Cognitive Assessment (MoCA) score in PD patients. We found significant correlations between MoCA score and CSF CRP levels in female patients and between CSF CRP and MDS-UPDRS part III score and MoCA score in male patients. In linear regression, CSF CRP could predict 6.9 and 10% of changes in MDS-UPDRS part III score in all PD patients male PD patients, respectively. In summary, we confirmed that CSF concentrations of CRP are in correlation with motor and non-motor severity in PD subjects. Our findings suggest that neuroinflammation plays an important role in the initiation and probably progression of PD motor and non-motor symptoms, which may give us a better insight into the underlying pathologic mechanisms in PD.

Indexed as

AgedC-Reactive ProteinCross-Sectional StudiesDatabases, FactualFemaleHumansHypokinesiaInflammationMaleMuscle RigidityParkinson DiseaseSeverity of Illness IndexTremorC-Reactive ProteinC-reactive proteinMotor symptomsNeuroinflammationNon-motor symptomsParkinson’ disease

Identifiers

PMID29980980
OpenAlexW2823503902

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.