ArticleWorld journal of microbiology & biotechnology2018
Determination and quantification of asiaticoside in endophytic fungus from Centella asiatica (L.) Urban.
Article in World journal of microbiology & biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 65 citations in OpenAlex.
- Mining the Hidden Pharmacopeia: Fungal Endophytes, Natural Products, and the Rise of AI-Driven Drug Discovery.International journal of molecular sciences · 2026Review
- Complete Genome Sequence ofJournal of fungi (Basel, Switzerland) · 2025Article
- Endophytic Species of the GenusMicroorganisms · 2025Review
- Morphological, phytochemical and genetic characterization ofSaudi journal of biological sciences · 2024Article
- Plants as the Extended Phenotype of Endophytes-The Actual Source of Bioactive Compounds.International journal of molecular sciences · 2023Review
- Morphological and molecular characterization of bacterial endophytes from Centella asiatica leaves.Journal, genetic engineering & biotechnology · 2022Article
- Coculturing of Mucor plumbeus and Bacillus subtilis bacterium as an efficient fermentation strategy to enhance fungal lipid and gamma-linolenic acid (GLA) production.Scientific reports · 2022Article
- Endophytic Fungal Terpenoids: Natural Role and Bioactivities.Microorganisms · 2022Review
- Phosphate solubilizing microorganisms isolated from medicinal plants improve growth of mint.PeerJ · 2022Article
- Biodegradation of poly (vinyl alcohol) by an orychophragmus rhizosphere-associated fungus Penicillium brevicompactum OVR-5, and its proposed PVA biodegradation pathway.World journal of microbiology & biotechnology · 2021Article
- Antibacterial assay guided isolation of a novel hydroxy-substituted pentacyclo ketonic compound from Pseudomonas aeruginosa MBTDCMFRI Ps04.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Fungal Endophytes as Efficient Sources of Plant-Derived Bioactive Compounds and Their Prospective Applications in Natural Product Drug Discovery: Insights, Avenues, and Challenges.Microorganisms · 2021Review
- Current State and Future Directions of Genetics and Genomics of Endophytic Fungi for Bioprospecting Efforts.Frontiers in bioengineering and biotechnology · 2021Review
- Tetracyclic and Pentacyclic Triterpenes with High Therapeutic Efficiency in Wound Healing Approaches.Molecules (Basel, Switzerland) · 2020Review
- Asiaticoside might attenuate bleomycin-induced pulmonary fibrosis by activating cAMP and Rap1 signalling pathway assisted by A2AR.Journal of cellular and molecular medicine · 2020Article
- Article
- Association between dipsacus saponin VI level and diversity of endophytic fungi in roots of Dipsacus asperoides.World journal of microbiology & biotechnology · 2019Article
- Insight Into Microbial Applications for the Biodegradation of Pyrethroid Insecticides.Frontiers in microbiology · 2019Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Centella asiatica (L.) Urban is a highly considered medicinal plant owing to its secondary metabolites asiaticoside, madecassoside, asiatic acid, and madecassic acid. The asiaticoside, one of the most important constituents of the plant, is a triterpenoid saponin having memory enhancement property. Given its medicinal properties, we isolated and characterized endophytic fungi from this plant with the aim to screen these microorganisms for asiaticoside production. In total, we isolated 13 endophytic fungi from the leaves of the plant, out of which one of the isolates produced asiaticoside. This asiaticoside producing isolate was identified as Colletotrichum gloeosporioides by internal transcribed spacer-based rDNA sequencing. The presence of asiaticoside in ethyl acetate extract of C. gloeosporioides was confirmed by LC-MS. The production of asiaticoside measured in relation to incubation time and subculture generation revealed presence of 62.29 ± 3.36 µg/100 mL of asiaticoside by C. gloeosporioides on the 15th day in first subculture generation followed by a decrease in subsequent generations. A similar trend was also shown by yield and growth curve of C. gloeosporioides. The asiaticoside production and yield were found to be positively correlated. This paper reported the production of asiaticoside by an endophytic fungus C. gloeosporioides for the first time. The present findings definitely provide an impetus to the production of asiaticoside by utilizing the endophytic source. Chemical compound studied in this article: Asiaticoside (PubChemCID: 108062).
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