ArticleJournal of neurology2018
Dysfunctional inhibitory control in Parkinson's disease patients with levodopa-induced dyskinesias.
Article in Journal of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Slowed Movement Stopping in Parkinson's Disease and Focal Dystonia is Improved by Standard Treatment.Scientific reports · 2019Trial
- Altered Cortical Gyrification, Functional Connections, and Underlying Neurotransmitter Information in Patients with Parkinson's Disease with Levodopa-Induced Dyskinesia.Neurology and therapy · 2025Article
- Identification of Key Active Constituents inInternational journal of molecular sciences · 2025Article
- Implication of regional selectivity of dopamine deficits in impaired suppressing of involuntary movements in Parkinson's disease.Neuroscience and biobehavioral reviews · 2024Review
- Altered perivascular spaces in subcortical white matter in Parkinson's disease patients with levodopa-induced dyskinesia.NPJ Parkinson's disease · 2024Article
- Effects of dopaminergic treatment on inhibitory control differ across Hoehn and Yahr stages of Parkinson's disease.Brain communications · 2024Article
- Impulsivity Traits in Parkinson's Disease: A Systematic Review and Meta-Analysis.Movement disorders clinical practice · 2023Review
- Cultural Differences in Inhibitory Control: An ALE Meta-Analysis.Brain sciences · 2023Review
- Altered dynamic functional network connectivity in levodopa-induced dyskinesia of Parkinson's disease.CNS neuroscience & therapeutics · 2023Article
- Gender difference in network relationship between inter-temporal decisions and prefrontal activation levels in internet gaming disorder.Psychoradiology · 2023Article
- From anticipation to impulsivity in Parkinson's disease.NPJ Parkinson's disease · 2022Article
- High PSQI score is associated with the development of dyskinesia in Parkinson's disease.NPJ Parkinson's disease · 2022Article
- Eye Tracking in Patients with Parkinson's Disease Treated with Nabilone-Results of a Phase II, Placebo-Controlled, Double-Blind, Parallel-Group Pilot Study.Brain sciences · 2022Article
- Reverse Visually Guided Reaching in Patients with Parkinson's Disease.Parkinson's disease · 2022Article
- Impulsivity traits and awareness of motor intention in Parkinson's disease: a proof-of-concept study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Engrafted primary type-2 astrocytes improve the recovery of the nigrostriatal pathway in a rat model of Parkinson's disease.Molecular and cellular biochemistry · 2021Article
- Cognitive impairment and levodopa induced dyskinesia in Parkinson's disease: a longitudinal study from the PACOS cohort.Scientific reports · 2021Article
- Mouse Tracking to Explore Motor Inhibition Processes in Go/No-Go and Stop Signal Tasks.Brain sciences · 2020Article
- Dysfunction in superior frontal gyrus associated with diphasic dyskinesia in Parkinson's disease.NPJ Parkinson's disease · 2020Article
- Altered interhemispheric synchrony in Parkinson's disease patients with levodopa-induced dyskinesias.NPJ Parkinson's disease · 2020Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionChronic dopamine replacement therapies in Parkinson's disease can induce side effects, such as levodopa-induced dyskinesias and impulse control disorders. A dysfunction of inhibitory brain networks has been related to both disorders; however, there is no clear behavioral evidence supporting this hypothesis. We aimed to determine whether PD patients with levodopa-induced dyskinesias show features of increased impulsivity in parallel with altered motor inhibition.
methodsTwo matched samples of Parkinson's disease patients with (n = 14) or without (n = 14) levodopa-induced dyskinesias and a control group (n = 10) participated in the study. All groups were evaluated by the Barratt Impulsiveness Scale-11 to assess impulsivity traits. Furthermore, participants performed a stop signal task to evaluate reactive-motor inhibition and a Go/NoGo task to evaluate proactive-inhibitory control. PD patients were tested both in OFF and ON levodopa medication.
resultsParkinson's disease patients with levodopa-induced dyskinesias showed higher impulsivity scores than PD patients without levodopa-induced dyskinesias. Dyskinetic patients presented also delayed stop signal reaction times indicating a worse performance in reactive inhibition. The slowness in inhibiting a motor command correlated with the impulsiveness scores. Furthermore, in the dyskinetic group, a positive correlation was found between stop reaction times and the severity of involuntary movements. Under the effect of levodopa, all patients were faster but dyskinetic patients were significantly less accurate in proactive inhibition.
conclusionInhibitory control is compromised in dyskinetic patients in parallel with increased impulsivity, revealing an impairment of motor and behavioral inhibitory control in Parkinson's disease patients with levodopa-induced dyskinesias.
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