Evidence map›Paper›PMID 29980839›Full record

ReviewWorld journal of urology2018

Malignant invasion of the central nervous system: the hidden face of a poorly understood outcome of prostate cancer.

Eliane Gouvêa de Oliveira Barros, Nathalia Meireles Da Costa, Celia Yelimar Palmero, Luis Felipe Ribeiro Pinto, Luiz Eurico Nasciutti, Antonio Palumbo

Abstract readReview
PubMed Publisher
In one paragraph

Review in World journal of urology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Eliane Gouvêa de Oliveira BarrosLaboratório de Interações Celulares, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro (UFRJ), Cidade Universitária-Ilha do Fundão, Rio de Janeiro, CEP 21941-902, Brazil. eligouveab@gmail.com.
Nathalia Meireles Da CostaPrograma de Carcinogênese Molecular, Centro de Pesquisas (CPQ), Instituto Nacional de Câncer (INCA), Rua André Cavalcanti, 37-Centro, Rio de Janeiro, CEP 20231-050, Brazil.
Celia Yelimar PalmeroLaboratório de Interações Celulares, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro (UFRJ), Cidade Universitária-Ilha do Fundão, Rio de Janeiro, CEP 21941-902, Brazil.
Luis Felipe Ribeiro PintoPrograma de Carcinogênese Molecular, Centro de Pesquisas (CPQ), Instituto Nacional de Câncer (INCA), Rua André Cavalcanti, 37-Centro, Rio de Janeiro, CEP 20231-050, Brazil.
Luiz Eurico NasciuttiLaboratório de Interações Celulares, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro (UFRJ), Cidade Universitária-Ilha do Fundão, Rio de Janeiro, CEP 21941-902, Brazil.
Antonio PalumboLaboratório de Interações Celulares, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro (UFRJ), Cidade Universitária-Ilha do Fundão, Rio de Janeiro, CEP 21941-902, Brazil. palumbo@icb.ufrj.br.
Instituto Nacional do Câncer · BRUniversidade Federal do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malignancies of the central nervous system include primary brain tumors and brain metastases, the latter being the major cause of intracranial neoplasms in adults. Although prostate cancer (PCa) brain metastases are not the most common source, recent data show that the relevance of prostate cancer brain metastases (PCBM) cannot be neglected. In this review, we focus on the molecular repertory as well as on the phenotypical similarities between PCBM and primary PCa, such as the cellular evolution and the maintenance of androgen-receptor expression. Moreover, the simultaneous occurrence of PCBM with other PCa metastatic sites and the significance of the clinical heterogeneity of the disease are also discussed. In addition, a potential relationship between the heterogeneous behavior exhibited by PCBM and the co-occurrence of malignant cell clusters with distinct genetic profiles is also hypothesized, as well as the prominent role of astrocytes in the establishment of PCBM.

Indexed as

AdenocarcinomaBrain NeoplasmsGene Expression Regulation, NeoplasticHumansMaleProstatic NeoplasmsReceptors, AndrogenReceptors, AndrogenAstrocytesBrain metastasisMicroenvironmentProstate cancerProstate cancer brain metastases

Identifiers

PMID29980839
OpenAlexW2861661685

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.